TLE2 - TLE family member 2, transcriptional corepressor Gene

Also Known as ESG; ESG2; GRG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7089

About TLE2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,997,644-3,047,635 (from NCBI)

This gene has 22 transcripts (splice variants), 103 orthologues and 6 paralogues. Ubiquitous expression in salivary gland (RPKM 17.9), fat (RPKM 13.6) and 24 other tissues.

Summary

Enables transcription corepressor activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

TLE2 Products (4)

mRNA Protein Name
NM_001144761.2 NP_001138233.1 transducin-like enhancer protein 2 isoform 2
NM_001144762.2 NP_001138234.1 transducin-like enhancer protein 2 isoform 3
NM_001300846.2 NP_001287775.1 transducin-like enhancer protein 2 isoform 4
NM_003260.5 NP_003251.2 transducin-like enhancer protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17041588 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
19460168 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19460168 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19460168 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLE2 Protein Structure

TLE_N

TLE_N: Groucho/TLE N-terminal Q-rich domain (1 - 131)

WD40

WD40: WD domain, G-beta repeat (455 - 484)

WD40

WD40: WD domain, G-beta repeat (543 - 575)

WD40

WD40: WD domain, G-beta repeat (582 - 617)

WD40

WD40: WD domain, G-beta repeat (664 - 698)

WD40

WD40: WD domain, G-beta repeat (712 - 739)

  • 0
  • 200
  • 400
  • 600
  • 743 a.a.
Protein Preferred Names Protein Names

transducin-like enhancer protein 2

  • enhancer of split groucho-like protein 2

TLE2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TLE2 Q04725 DDB1 Homo sapiens Q16531
Anti Bait CoIP
17041588
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bladder Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Bladder

  • Epidermoid Carcinoma Of The Urinary Bladder

  • Carcinoma Squamous Cell Bladder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14564 TLE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20827 Tle2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27341 Tle2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TLE2 VGNC VGNC:49981
Canis familiaris TLE2 VGNC VGNC:55001
Mus musculus TLE2 MGD MGI:104635
Felis catus TLE2 VGNC VGNC:66209
Rattus norvegicus TLE2 RGD RGD:1306665
Macaca mulatta TLE2 VGNC VGNC:78365
Others TLE2 NCBI