KBTBD7 - kelch repeat and BTB domain containing 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84078

About KBTBD7

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,189,834-41,194,569 (from NCBI)

This gene has 1 transcript (splice variant), 81 orthologues and 54 paralogues.

Summary

The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]

KBTBD7 Products (1)

mRNA Protein Name
NM_032138.7 NP_115514.2 kelch repeat and BTB domain-containing protein 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
25684205 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
25684205 GOA
involved in regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
25684205 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
25684205 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KBTBD7 Protein Structure

BTB

BTB: BTB/POZ domain (54 - 166)

BACK

BACK: BTB And C-terminal Kelch (173 - 273)

Kelch_1

Kelch_1: Kelch motif (427 - 469)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
Protein Preferred Names Protein Names

kelch repeat and BTB domain-containing protein 7

  • kelch repeat and BTB (POZ) domain containing 7

KBTBD7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KBTBD7 Q8WVZ9 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
KBTBD7 Q8WVZ9 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
KBTBD7 Q8WVZ9 KBTBD8 Homo sapiens Q8NFY9
Anti Tag CoIP
28514442
Intra
KBTBD7 Q8WVZ9 KBTBD8 Homo sapiens Q8NFY9
Anti Tag CoIP
33961781
Intra
KBTBD7 Q8WVZ9 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
20562859
Intra
KBTBD7 Q8WVZ9 MAP1LC3C Homo sapiens Q9BXW4
ITC
25684205
Intra
KBTBD7 Q8WVZ9 KLF15 Homo sapiens Q9UIH9
Validated Y2H
32296183
Intra
KBTBD7 Q8WVZ9 KLF15 Homo sapiens Q9UIH9
Y2H Array
32296183
Intra
KBTBD7 Q8WVZ9 KLF15 Homo sapiens Q9UIH9
Y2H Prey Pooling
32296183
Intra
KBTBD7 Q8WVZ9 PSME3 Homo sapiens P61289
Y2H Array
32296183
Intra
KBTBD7 Q8WVZ9 PSME3 Homo sapiens P61289
Y2H Prey Pooling
32296183
Intra
KBTBD7 Q8WVZ9 MAP1LC3B Homo sapiens Q9GZQ8
ITC
25684205
Intra
KBTBD7 Q8WVZ9 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra
KBTBD7 Q8WVZ9 MAP1LC3B Homo sapiens Q9GZQ8
Y2H
21900206
Intra
KBTBD7 Q8WVZ9 CCDC106 Homo sapiens Q9BWC9
Y2H Prey Pooling
32296183
Intra
KBTBD7 Q8WVZ9 CCDC106 Homo sapiens Q9BWC9
Validated Y2H
32296183
Intra
KBTBD7 Q8WVZ9 CCDC106 Homo sapiens Q9BWC9
Y2H Array
32296183
Intra
KBTBD7 Q8WVZ9 GABARAP Homo sapiens O95166
Anti Tag CoIP
25684205
Intra
KBTBD7 Q8WVZ9 GABARAP Homo sapiens O95166
ITC
25684205
Intra
KBTBD7 Q8WVZ9 GABARAP Homo sapiens O95166
Peptide Array
25684205
Intra
KBTBD7 Q8WVZ9 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
KBTBD7 Q8WVZ9 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra
KBTBD7 Q8WVZ9 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra
KBTBD7 Q8WVZ9 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
25684205
Intra
KBTBD7 Q8WVZ9 GABARAPL2 Homo sapiens P60520
Y2H
21900206
Intra
KBTBD7 Q8WVZ9 GABARAPL2 Homo sapiens P60520
ITC
25684205
Intra
KBTBD7 Q8WVZ9 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Intra
KBTBD7 Q8WVZ9 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
25684205
Intra
KBTBD7 Q8WVZ9 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
25416956
Intra
KBTBD7 Q8WVZ9 GABARAPL1 Homo sapiens Q9H0R8
ITC
25684205
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07095 KBTBD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KBTBD7 VGNC VGNC:56746
Felis catus KBTBD7 VGNC VGNC:102238
Macaca mulatta KBTBD7 VGNC VGNC:73903
Bos taurus KBTBD7 VGNC VGNC:53820
Mus musculus KBTBD7 MGD MGI:2685141
Rattus norvegicus KBTBD7 RGD RGD:6501695
Others KBTBD7 NCBI