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MED10 - mediator complex subunit 10 Gene

Also Known as L6; NUT2; TRG20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84246

About MED10

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:6,371,874-6,378,547 (from NCBI)

This gene has 3 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in bone marrow (RPKM 22.5), lymph node (RPKM 18.2) and 25 other tissues.

Summary

MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

MED10 Products (1)

mRNA	Protein	Name
NM_032286.3	NP_115662.2	mediator of RNA polymerase II transcription subunit 10

MED10 Protein Structure

Med10

0
100
135 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 10	TRG-17

MED10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MED10	Q9BTT4	ARHGDIG	Homo sapiens	Q99819	Y2H Array	32296183
Intra	MED10	Q9BTT4	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	MED10	Q9BTT4	TRIM45	Homo sapiens	Q9H8W5-2	Validated Y2H	32296183
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	24882805
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	33961781
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	15175163
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Ion Exchange Chrom	15175163
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	EM	24882805
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	35271311
Intra	MED10	Q9BTT4	MED7	Homo sapiens	O43513	Anti Tag CoIP	14576168

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cri-Du-Chat Syndrome	5p Deletion Syndrome 5p Partial Monosomy Syndrome Monosomy 5p Cat Cry Syndrome Chromosome 5p Deletion Syndrome Cri Du Chat Syndrome 5p- Syndrome 5p Minus Syndrome Chromosome 5p- Syndrome Chromosome 5 Short Arm Deletion Syndrome Chromosome 5p Deletion Deletion 5p Cri Du Chat 5p Partial Deletion Syndrome Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
Intellectual Developmental Disorder, Autosomal Dominant 48	Mental Retardation, Autosomal Dominant 48 MRD48 Autosomal Dominant Mental Retardation 48 Autosomal Dominant Intellectual Developmental Disorder 48
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS08279	MED10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19712	Med10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26208	Med10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MED10	RGD	RGD:1310128
Mus musculus	MED10	MGD	MGI:106331
Macaca mulatta	MED10	VGNC	VGNC:110451
Bos taurus	MED10	VGNC	VGNC:31347
Canis familiaris	MED10	VGNC	VGNC:43118
Others	MED10	NCBI