C2CD5 - C2 calcium dependent domain containing 5 Gene

Also Known as CDP138; KIAA0528

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9847

About C2CD5

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:22,448,583-22,544,542 (from NCBI)

This gene has 18 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 12.3), colon (RPKM 12.2) and 25 other tissues.

Summary

Enables calcium ion binding activity and calcium-dependent phospholipid binding activity. Involved in cellular response to Insulin stimulus; intracellular protein transmembrane transport; and positive regulation of transport. Located in several cellular components, including centriolar satellite; cytoplasmic vesicle membrane; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

C2CD5 Products (18)

mRNA	Protein	Name
NM_001286173.2	NP_001273102.1	C2 domain-containing protein 5 isoform c
NM_001286174.3	NP_001273103.1	C2 domain-containing protein 5 isoform a
NM_001286175.2	NP_001273104.1	C2 domain-containing protein 5 isoform b
NM_001286176.2	NP_001273105.1	C2 domain-containing protein 5 isoform a
NM_001286177.2	NP_001273106.1	C2 domain-containing protein 5 isoform d
NM_001385322.1	NP_001372251.1	C2 domain-containing protein 5 isoform f
NM_001385323.1	NP_001372252.1	C2 domain-containing protein 5 isoform g
NM_001385324.1	NP_001372253.1	C2 domain-containing protein 5 isoform h
NM_001385325.1	NP_001372254.1	C2 domain-containing protein 5 isoform i
NM_001385326.1	NP_001372255.1	C2 domain-containing protein 5 isoform j
NM_001385327.1	NP_001372256.1	C2 domain-containing protein 5 isoform k
NM_001385328.1	NP_001372257.1	C2 domain-containing protein 5 isoform l
NM_001385329.1	NP_001372258.1	C2 domain-containing protein 5 isoform m
NM_001385330.1	NP_001372259.1	C2 domain-containing protein 5 isoform n
NM_001385331.1	NP_001372260.1	C2 domain-containing protein 5 isoform o
NM_001385332.1	NP_001372261.1	C2 domain-containing protein 5 isoform p
NM_001385333.1	NP_001372262.1	C2 domain-containing protein 5 isoform q
NM_014802.3	NP_055617.1	C2 domain-containing protein 5 isoform e

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	21907143	GOA
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	21907143	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	21907143	GOA
involved in intracellular protein transmembrane transport	IMP IMP: Inferred from mutant phenotype	21907143	GOA
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	21907143	GOA
involved in positive regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	21907143	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cell cortex	IDA IDA: Inferred from direct assay	21907143	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	21907143	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21907143	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	21907143	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C2CD5 Protein Structure

C2

0
200
400
600
800
1000 a.a.

Protein Preferred Names	Protein Names
C2 domain-containing protein 5	138 kDa C2 domain-containing phosphoprotein

Related Diseases

Diseases	Alias
Protoplasmic Astrocytoma	Protoplasmic Astrocytic Tumor Astrocytoma Protoplasmic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01741	C2CD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	C2CD5	MGD	MGI:1921991
Felis catus	C2CD5	VGNC	VGNC:60230
Canis familiaris	C2CD5	VGNC	VGNC:38590
Macaca mulatta	C2CD5	VGNC	VGNC:70665
Bos taurus	C2CD5	VGNC	VGNC:26636
Rattus norvegicus	C2CD5	RGD	RGD:1304592
Others	C2CD5	NCBI