GSD-11
GSD-11 is a potent and selective anti-austerity agent. GSD-11 inhibits the cell migration and colony formation of PANC-1 cells. GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 has the potential for the research of pancreatic cancer[1].
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- Formel: C20H28O2
- Molecular Weight:300.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PANC-1 | IC50 |
3.5 μM
Compound: GSD-11
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Preferential cytotoxic activity against human PANC-1 cells in Dulbecco's modified Eagle's medium
Preferential cytotoxic activity against human PANC-1 cells in Dulbecco's modified Eagle's medium
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[PMID: 34942553] |
GSD-11 (0,1, 10, 100, 1000 µM) shows potent cytotoxicity against PANC-1 cells with PC50 value of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM)[1].
GSD-11 (10 µM, 24 h) induces morphological change in PANC-1 cells[1].
GSD-11 (3, 5 µM, 24 h) inhibits the migration of PANC-1 tumor cells[1].
GSD-11 (1, 3, 5 µM, 24 h) shows strong colony formation inhibitory effect in PANC-1 tumor cells[1].
GSD-11 (2.5, 5, 10 µM) inhibits the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PANC-1 cells
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Concentration:0,1, 10, 100, 1000 µM
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Incubation Time:
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Result:Showed preferential cytotoxicity against PANC-1 cells with PC50 of 0.72 µM in nutrient-deprived medium (NDM), and IC50 value of 3.5 µM in Dulbecco’s modified Eagle’s medium (DMEM).
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Cell Line:PANC-1 cells
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Concentration:2.5, 5, 10 µM
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Incubation Time:
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Result:Inhibited the survival of PANC-1 cells through the inhibition of the Akt/mTOR pathway under NDM conditions.
Chemical Information
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Molecular Weight 300.44
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Formel C20H28O2
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SMILES
[H][C@@]12CC[C@]3([C@@]4(CC(C([C@]4(CC[C@@]3([C@]1(CCC(C2)=O)C)[H])C)=C)=O)[H])[H]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
GSD-11 Related Classifications
HY-146738 Related Classifications
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