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Art. -Nr.: HY-N11082

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Isocucurbitacin D

Isocucurbitacin D is an antitumor agent.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 68422-20-8
Formel: C₃₀H₄₄O₇
Molecular Weight:516.67

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Isocucurbitacin D Chemical Structure

CAS. Nr.: 68422-20-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isocucurbitacin D is an antitumor agent^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	13.8 μM Compound: 4	Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay Hepatoprotective activity in human HepG2 cells assessed as inhibition of CCl4-induced toxicity after 24 hrs by MTT assay	[PMID: 21459003]
HepG2	IC₅₀	80.33 μM Compound: 4	Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay	[PMID: 21459003]
HSC-T6	EC₅₀	0.06 μM Compound: 4	Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay Antiproliferative activity against serum-stimulated rat HSC-T6 cells after 24 hrs by MTT assay	[PMID: 21459003]
HSC-T6	IC₅₀	8.7 μM Compound: 4	Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay Cytotoxicity against rat HSC-T6 cell after 24 hrs by MTT assay	[PMID: 21459003]

In Vitro

Isocucurbitacin D inhibits tumor cell growth with ED₅₀s of 0.06, 0.2, 0.6, 0.8 and 1.2 μg/mL against SK-MEL-2, A549, XF498, HCT15 and SK-OV-3 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, MDA MB 231, A2780, A2780 CP, HepG2 and HCT-116 cells
Concentration:

0-100 μM
Incubation Time:

48 h
Result:

Inhibited cell proliferation with IC₅₀s of 12.0, 30.7, 37.8, 47.9, >100 and >100 μM against MDA MB 231, HCT-116, HepG2, MCF-7, A2780 and A2780 CP, respectively.

Chemical Information

CAS. Nr. 68422-20-8
Molecular Weight 516.67
Formel C₃₀H₄₄O₇
SMILES

CC(O)(/C=C/C([C@](O)([C@H]1[C@H](C[C@@]2([C@@]1(CC([C@@]3([C@H]2CC=C4[C@H]3CC([C@H](C4(C)C)O)=O)C)=O)C)C)O)C)=O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ryu S Y, et al. Antitumor activity of Trichosanthes kirilowii. Archives of Pharmacal Research, 1994, 17: 348-353.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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