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Art. -Nr.: HY-119163

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L-902688

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

L-902688 is a potent, selective and orally active EP4 receptor agonist with a K_i of 0.38 nM and an EC₅₀ of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.

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Reinheit: 99.0%
CAS. Nr.: 634193-54-7
Formel: C₂₁H₂₇F₂N₅O₂
Molecular Weight:419.47

Speicherung:

Solution, -20°C, 2 years

L-902688 Chemical Structure

CAS. Nr.: 634193-54-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[2]

EP4

0.38 nM (Ki)

EP4

0.6 nM (EC₅₀)

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

L-902688 (1 µM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human umbilical vein endothelial cells (HUVECs)
Concentration:

1 µM
Incubation Time:

24 hours
Result:

Attenuated TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression.

In Vivo

L-902688 (0.25-1 µg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Sprague-Dawley rats injected with crotaline to induce pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy^[1]
Dosage:

0.25 µg/kg/day, 0.4 µg/kg/day or 1 µg/kg/day
Administration:

Intraperitoneal injection; daily; for 3 weeks
Result:

Reduced right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.

Chemical Information

CAS. Nr. 634193-54-7
Appearance Liquid
Molecular Weight 419.47
Formel C₂₁H₂₇F₂N₅O₂
Color Colorless to light yellow
SMILES

O[C@@]([H])(C(F)(C1=CC=CC=C1)F)/C=C/[C@@H](CCC2=O)N2CCCCCCC3=NN=NN3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Solution, -20°C, 2 years

Publications (3)

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Journal Impact Factor

Nat Neurosci

NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. [Abstract]

2024 Aug;27(8):1534-1544. PMID: 38802591
Seoul National University

2030.
bioRxiv

2024 September 14.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lai YJ, et al. EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2018 Mar 3;19(3). pii: E727. [Content Brief]

[2]. [2]Young, R.N., Billot, X., Han, Y., et al. Discovery and synthesis of a potent, selective and orally bioavailable EP4 receptor agonist. Heterocycles. 2004, 64, 437-445.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

L-902688

3 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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L-902688

Publications Citing Use of MedChemExpress (MCE) L-902688

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

L-902688 Related Classifications

HY-119163 Related Classifications