country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-130332

Copy Link Print Information

Mitomycin A

Kundenbewertung

Based on 1 Customer Validation

Mitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.3%
CAS. Nr.: 4055-39-4
Formel: C₁₆H₁₉N₃O₆
Molecular Weight:349.34

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Mitomycin A Chemical Structure

CAS. Nr.: 4055-39-4

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.006 μg/mL Compound: 16	in vitro anticancer activity against cultured A549 human tumor(lung) cell line in vitro anticancer activity against cultured A549 human tumor(lung) cell line	[PMID: 11585450]
CCRF S-180	ED₅₀	1.1 μg/mL Compound: 28	Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days Antitumor activity against mouse S180 cells implanted in ip dosed ddY mouse assessed as tumor volume after 7 days	[PMID: 19540628]
CCRF S-180	ED₅₀	1.3 mg/kg Compound: mitomycin A	Effective dose that gave 50 percent inhibition of sarcoma 180 tumor growth in ddY mice Effective dose that gave 50 percent inhibition of sarcoma 180 tumor growth in ddY mice	[PMID: 8021919]
HCT-8	IC₅₀	0.006 μg/mL Compound: 16	in vitro inhibition of tumor cell growth in cultured HCT-8 human tumor cell line in vitro inhibition of tumor cell growth in cultured HCT-8 human tumor cell line	[PMID: 11585450]
HeLa	IC₅₀	0.0024 μM Compound: mitomycin A	In vitro anticellular activity tested against HeLa S3 cells In vitro anticellular activity tested against HeLa S3 cells	[PMID: 8021918]
HeLa	IC₅₀	0.0024 μM Compound: mitomycin A	In vitro anticellular activity against HeLa S3 cells In vitro anticellular activity against HeLa S3 cells	[PMID: 8021919]
HepG2	IC₅₀	0.008 μg/mL Compound: 16	in vitro inhibition of tumor cell growth in cultured HepG2 human tumor cell line in vitro inhibition of tumor cell growth in cultured HepG2 human tumor cell line	[PMID: 11585450]
KB	IC₅₀	0.008 μg/mL Compound: 16	in vitro anticancer activity against cultured KB(epidermoid) human tumor cell line in vitro anticancer activity against cultured KB(epidermoid) human tumor cell line	[PMID: 11585450]
L1210	IC₅₀	0.0023 μM Compound: 6	Inhibitory concentration on multidrug-resistant L1210 leukemia cells. Inhibitory concentration on multidrug-resistant L1210 leukemia cells.	[PMID: 1906107]
L1210	IC₅₀	0.0003 μM Compound: 6	Inhibitory concentration on parentral (sensitive) L1210 leukemia cells. Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.	[PMID: 1906107]
L1210	IC₅₀	0.3 nM Compound: 6	Inhibitory concentration on parentral (sensitive) L1210 leukemia cells. Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.	[PMID: 1906107]
MCF7	IC₅₀	0.045 μg/mL Compound: 16	in vitro inhibition of tumor cell growth in cultured MCF-7 human tumor cell line in vitro inhibition of tumor cell growth in cultured MCF-7 human tumor cell line	[PMID: 11585450]
MCF7	IC₅₀	0.63 nM Compound: 20	Antitumor potency on human breast MCF-7 cell lines. Antitumor potency on human breast MCF-7 cell lines.	[PMID: 1906109]
P388	IC₅₀	0.24 nM Compound: 20	Antitumor potency on P388 leukemia cells in culture Antitumor potency on P388 leukemia cells in culture	[PMID: 1906109]
PC-3	IC₅₀	0.02 μg/mL Compound: 16	in vitro inhibition of tumor cell growth in cultured PC-3 human tumor cell line in vitro inhibition of tumor cell growth in cultured PC-3 human tumor cell line	[PMID: 11585450]
U-87MG ATCC	IC₅₀	0.009 μg/mL Compound: 16	in vitro anticancer activity against cultured U87MG (glioblastoma) human tumor cell line in vitro anticancer activity against cultured U87MG (glioblastoma) human tumor cell line	[PMID: 11585450]
WiDr	IC₅₀	0.052 nM Compound: 20	Antitumor potency on human colon WIDR cell lines. Antitumor potency on human colon WIDR cell lines.	[PMID: 1906109]

In Vitro

Mitomycin A (0.05-5 μg/mL; 24 h) inhibits the spontaneous migration of WEHI-3 mouse monocytes in a concentration-dependent manner^[1].
Mitomycin A (0.25 μg/mL; 65 h) significantly inhibits the production of migration inhibitory factor (MIF) by pokeweed mitogen-activated human lymphocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay^[1]

Cell Line:

WEHI-3 murine myelomonocytic leukemia cells
Concentration:

0.05 μg/mL; 0.1 μg/mL; 0.5 μg/mL; 5 μg/mL
Incubation Time:

24 h
Result:

Exhibited a migration index (MI) of 1.01 ± 0.05 at 0.05 μg/mL.
Showed a migration index (MI) of 1.03 ± 0.03 at 0.1 μg/mL.
Reduced the mean migration index (MI) to 0.65 ± 0.01 at 0.5 μg/mL, with a statistically significant decrease.
Lowered the mean migration index (MI) to 0.52 ± 0.02 at 5 μg/mL, with a statistically significant decrease.
Caused no statistically significant decreases in migration at 0.05 and 0.1 μg/mL.

Chemical Information

CAS. Nr. 4055-39-4
Appearance Solid
Molecular Weight 349.34
Formel C₁₆H₁₉N₃O₆
Color Purple to purplish red
SMILES

O=C1C(C)=C(OC)C(C2=C1N3[C@@]([C@](N4)([H])[C@]4([H])C3)(OC)[C@@H]2COC(N)=O)=O
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986;172(1-2):120-127. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen