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Art. -Nr.: HY-183623

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ProAlk01

ProAlk01 is a protein alkylating agent that serves as a toxin payload for ADCs. ProAlk01 localizes to the cytoplasm and exerts cytotoxic effects mainly by alkylating cytoplasmic proteins rather than binding to DNA. ProAlk01 induces cell cycle arrest, apoptosis, and immunogenic cell death. ProAlk01 can be used in the research of solid tumors.

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CAS. Nr.: 1296670-84-2
Formel: C₃₁H₂₈Cl₂N₂O₄
Molecular Weight:563.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ProAlk01 Chemical Structure

CAS. Nr.: 1296670-84-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

Alle ADC Payloads Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.7 nM Compound: BDA 2	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 30620194]

In Vitro

ProAlk01 (1-100 pM) exhibits potent in vitro cytotoxic activity across a broad panel of solid tumor cell lines with IC₅₀ values in the 1-100 pM range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1296670-84-2
Molecular Weight 563.47
Formel C₃₁H₂₈Cl₂N₂O₄
SMILES

O=C(N1C[C@H](C2=C1C=C(C3=C2C=CC=C3)O)CCl)CCCC(N4C[C@H](C5=C4C=C(C6=C5C=CC=C6)O)CCl)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Turska A, et al. PA289: A first-in-class prodrug payload with a novel mechanism of action and favorable efficacy/safety profile. Cancer Research. 2026 Apr 3;86(7_Supplement):1712-.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
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ProAlk01

Alle ADC Payloads Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ProAlk01 Related Classifications

HY-183623 Related Classifications