IGFBP-4
IGFBP-4 is a widely expressed IGF-binding protein that consistently inhibits IGF action, blunting IGF-1 and IGF-II signaling in the tissues where it acts. Its regulatory signature is proteolysis: the metalloproteinase PAPP-A (pregnancy-associated plasma protein A) specifically cleaves IGFBP-4, releasing free IGFs locally and making the IGFBP-4/PAPP-A axis a spatially precise mechanism for tuning growth factor availability. PAPP-A is abundant in placenta and serves as a Down syndrome screening marker, and heightened PAPP-A activity has been linked to atherosclerotic plaque growth. Physiological studies assign IGFBP-4 roles in bone remodeling, vascular biology and reproduction, and knockout mice show impaired embryonic growth and cardiac development.
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IGFBP-4 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
