SPHK
Sphingosine kinases govern the sphingolipid rheostat by phosphorylating sphingosine into sphingosine-1-phosphate (S1P), counterbalancing pro-apoptotic ceramide. Two human enzymes exist: SPHK1, largely cytosolic and translocated to the plasma membrane upon activation, and SPHK2, which resides in the nucleus and endoplasmic reticulum, inhibits histone deacetylases, and converts the prodrug fingolimod (FTY720) into its active receptor agonist. Secreted S1P acts on the five S1P receptor GPCRs to regulate lymphocyte egress, vascular maturation and endothelial barrier integrity. SPHK1 is overexpressed in many tumors and correlates with poor outcome, motivating inhibitors such as ABC294640 and PF-543 in preclinical and early clinical studies.
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SPHK Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
