QLH-11811
QLH-11811 is a mutant-selective EGFR tyrosine kinase inhibitor. QLH-11811 reversibly inhibits EGFR-19del/T790M/C797S and EGFR-L858R/T790M/C797S tyrosine kinase activity (IC50 = 2.6 nM and 3.1 nM, respectively), thereby overcoming C797S-mediated drug resistance. QLH-11811 exhibits weaker inhibitory activity against wild-type EGFR than against mutant EGFR variants. QLH-11811 can be used for research on advanced non-small cell lung cancer.
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- CAS. Nr.: 2595202-02-9
- Formel: C29H31BrN9O3P
- Molecular Weight:664.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2595202-02-9
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Molecular Weight 664.49
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Formel C29H31BrN9O3P
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SMILES
CN1C=C(C=N1)C2=C(C=C(C(NC3=NC=C(C(NC4=CC=C5N=CC=NC5=C4P(C)(C)=O)=N3)Br)=C2)OC)N6CCOCC6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
QLH-11811 Related Classifications
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