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Art. -Nr.: HY-120661

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T-1840383

T-1840383 is a potent, ATP-competitive inhibitor of c-Met/VEGFR-2, with the IC₅₀s of 1.9 nM, 7.7 nM, 2.2 nM and 5.5 nM for c-Met, VEGFR1, VEGFR2 and VEGFR3, respectively.

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CAS. Nr.: 1195779-24-8
Formel: C₃₀H₂₅ClFN₅O₄
Molecular Weight:574.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

T-1840383 Chemical Structure

CAS. Nr.: 1195779-24-8

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

T-1840383 is a potent, ATP-competitive inhibitor of c-Met/VEGFR-2, with the IC₅₀s of 1.9 nM, 7.7 nM, 2.2 nM and 5.5 nM for c-Met, VEGFR1, VEGFR2 and VEGFR3, respectively^[1].

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	1.8 nM Compound: 26	Cytotoxicity against VEGF-stimulated HUVEC assessed as growth inhibition after 120 hrs by CCK-8 assay Cytotoxicity against VEGF-stimulated HUVEC assessed as growth inhibition after 120 hrs by CCK-8 assay	[PMID: 24216091]
MKN-45	IC₅₀	5 nM Compound: 26	Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by CCK-8 assay Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by CCK-8 assay	[PMID: 24216091]

Chemical Information

CAS. Nr. 1195779-24-8
Molecular Weight 574.00
Formel C₃₀H₂₅ClFN₅O₄
SMILES

O=C(NC1=CC=C(C(F)=C1)OC2=CN3C(C=C2)=NC(NC(C4CC4)=O)=C3)C5=CC=C(N(C5=O)C6=CC=CC=C6)C.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Z Yuan, et al. Advances on receptor tyrosine kinase inhibitors taking c-Met as anti-tumor target. Journal of China Pharmaceutical University.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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T-1840383

Alle VEGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

T-1840383 Related Classifications

HY-120661 Related Classifications