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Cat. No.: HY-186198

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FTS-MOM

(Synonyms: Salirasib methoxymethyl ester)

FTS-MOM (Salirasib methoxymethyl ester), a Salirasib (FTS) (HY-14754) derivative, is a selective Rap1 inhibitor with selectivity over Ras. FTS-MOM inhibits GTP loading of Rap1 in quiescent and activated T cells. FTS-MOM inhibits Rap1-dependent T cell adhesion to ICAM-1.

For research use only. We do not sell to patients.

CAS No.: 1092521-71-5
Formula: C₂₄H₃₄O₃S
Molecular Weight:402.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FTS-MOM Chemical Structure

CAS No.: 1092521-71-5

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Ras Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PANC-1	IC₅₀	12 μM Compound: FTS-MOME	Cytotoxicity against human PANC1 cells after 5 to 7 days Cytotoxicity against human PANC1 cells after 5 to 7 days	[PMID: 19072665]

In Vitro

FTS-MOM (50 μM; overnight) inhibits antigen receptor-induced Rap1 activation in Jurkat T cells by 53%^[1].
FTS-MOM (50 μM; overnight) inhibits Rap1-dependent adhesion of anti-CD3-stimulated Jurkat T cells to ICAM-1, reducing adhesion to ~25% of stimulated control levels^[1].
FTS-MOM (50 μM; overnight) acts as a Rap1-selective inhibitor in Panc-1 cells, strongly reducing GTP-Rap1 levels while only weakly inhibiting GTP-Ras levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1092521-71-5
Molecular Weight 402.59
Formula C₂₄H₃₄O₃S
SMILES

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC1=C(C=CC=C1)C(OCOC)=O
Synonyms

Salirasib methoxymethyl ester
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mor A, et al. Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor. J Invest Dermatol. 2011;131(10):2040-2048. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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FTS-MOM

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

FTS-MOM Related Classifications

HY-186198 Related Classifications