Arg2 - arginase type II Gene

Also Known as AII

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11847

Summary

Predicted to enable Arginase activity; manganese ion binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process; and negative regulation of cytokine production. Acts upstream of or within striated muscle contraction and ureteric bud development. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (Arginase 2). [provided by Alliance of Genome Resources, Apr 2022]

Arg2 Products (1)

mRNA Protein Name
NM_009705.3 NP_033835.1 arginase-2, mitochondrial precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
25009204 MGI
involved in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
27745970 MGI
involved in negative regulation of chemokine (C-C motif) ligand 4 production IMP
IMP: Inferred from mutant phenotype
27074721 MGI
involved in negative regulation of chemokine (C-C motif) ligand 5 production IMP
IMP: Inferred from mutant phenotype
27074721 MGI
involved in negative regulation of defense response to bacterium IMP
IMP: Inferred from mutant phenotype
27074721 MGI
involved in negative regulation of interleukin-13 production IMP
IMP: Inferred from mutant phenotype
27214549 MGI
involved in negative regulation of interleukin-17 production IMP
IMP: Inferred from mutant phenotype
27214549 MGI
involved in negative regulation of macrophage inflammatory protein 1 alpha production IMP
IMP: Inferred from mutant phenotype
27074721 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
27074721 MGI
involved in negative regulation of type 2 immune response IMP
IMP: Inferred from mutant phenotype
27214549 MGI
involved in regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
27074721 MGI
involved in regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
27214549 MGI
acts upstream of or within striated muscle contraction IMP
IMP: Inferred from mutant phenotype
16537391 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
16545622 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
25009204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arginase-2, mitochondrial

  • arginase II

  • kidney-type arginase

  • non-hepatic arginase

  • type II arginase

Recombinant Arg2 Proteins

Cat. No. Product Name Accession Purity
HY-P72090 Arginase-2/ARG2 Protein, Mouse (His-SUMO) O08691 (V23-I354) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16254 Hydrocortamate hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112885 nor-NOHA / Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112885B nor-NOHA monoacetate 99.99% Unkown
HY-112885C nor-NOHA dihydrochloride 99.61% Unkown
HY-112885A nor-NOHA acetate 99.52% Unkown
HY-RS00908 ARG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P4750 Acetyl-(D-Arg2)-GRF (1-29) amide (human) Antagonist 99.67% Unkown
HY-P10555 (D-Arg2, Sar 4)-Dermorphin (1-4) Agonist / Unkown
HY-RS17404 Arg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23859 Arg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arg2 NCBI NCBI:384