SCTR - secretin receptor Gene

Also Known as SR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6344

About SCTR

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,439,843-119,524,483 (from NCBI)

This gene has 5 transcripts (splice variants), 130 orthologues and 42 paralogues. Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic Cancer and autism. [provided by RefSeq, Jul 2008]

SCTR Products (13)

mRNA Protein Name
NM_002980.3 NP_002971.2 secretin receptor precursor
XM_011511621.3 XP_011509923.1 secretin receptor isoform X3
XR_007079571.1
XR_922984.3
XM_047445399.1 XP_047301355.1 secretin receptor isoform X1
XM_047445403.1 XP_047301359.1 secretin receptor isoform X7
XM_047445402.1 XP_047301358.1 secretin receptor isoform X6
XR_001738888.2
XR_001738889.2
XM_047445401.1 XP_047301357.1 secretin receptor isoform X5
XM_047445400.1 XP_047301356.1 secretin receptor isoform X2
XM_047445404.1 XP_047301360.1 secretin receptor isoform X8
XM_017004670.2 XP_016860159.2 secretin receptor isoform X4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
7612008 GOA
enables secretin receptor activity IDA
IDA: Inferred from direct assay
7612008 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
7612008 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
23264731 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCTR Protein Structure

HRM

HRM: Hormone receptor domain (64 - 124)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (141 - 384)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

secretin receptor

  • pancreatic secretin receptor

SCTR Antibodies

Cat. No. Product Name Application Reactivity
HY-P810158 secretin receptor Antibody (YA9502) WB, IP, ELISA human
HY-P811107 Secretin Receptor Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Isolated Growth Hormone Deficiency, Type Ib

  • Isolated Growth Hormone Deficiency Type Ib

  • IGHD1B

  • Ighd Ib

  • Growth Hormone Deficiency, Isolated, Type Ib

  • Congenital Ighd Type Ib

  • Congenital Isolated Gh Deficiency Type Ib

  • Congenital Isolated Growth Hormone Deficiency Type Ib

  • Dwarfism Of Sindh

  • Pituitary Dwarfism I

  • Isolated Growth Hormone Deficiency Type 1b

  • Ighd 1b

  • Growth Hormone Deficiency, Isolated, 1b
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Retinitis Pigmentosa 18

  • RP18

  • Retinitis Pigmentosa-18

  • Retinitis Pigmentosa, Type 18
Pancreas Disease

  • Abnormality Of The Pancreas

  • Pancreatic Diseases
X-Linked Nephrogenic Diabetes Insipidus

  • Nephrogenic Diabetes Insipidus Type 1

  • Doid:0081060
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Gastrinoma

  • Gastrin Cell Tumour

  • Gastrin Secreting Tumor

  • Malignant Gastrinoma

  • Gastrinoma, Malignant
Metaphyseal Chondrodysplasia, Jansen Type

  • Metaphyseal Chondrodysplasia, Murk Jansen Type

  • MCDJ

  • Jansen'S Metaphyseal Chondrodysplasia

  • Murk Jansen Type Metaphyseal Chondrodysplasia

  • Jansen Type Metaphyseal Chondrodysplasia

  • Jansen Disease

  • Jansen Metaphyseal Chondrodysplasia

  • Jansen Metaphyseal Dysostosis

  • Metaphyseal Chondrodysplasia Murk Jansen Type

  • Chondrodysplasia, Metaphyseal, Murk Jansen Type
Polycystic Liver Disease

  • Autosomal Dominant Polycystic Liver Disease

  • Isolated Polycystic Liver Disease

  • Pcld

  • Congenital Cystic Liver Disease

  • Congenital Hepatic Cyst

  • Fibrocystic Liver Disease

  • Isolated Autosomal Dominant Polycystic Liver Disease

  • Adpcld

  • Liver Disease, Polycystic

  • Multiple Cysts Of Liver

  • Pld - [Polycystic Liver Disease]

  • Polycystic Liver Disorder

  • Polycystic Liver

  • Congenital Polycystic Disease Of Liver

  • Congenital Polycystic Liver Disease
Suppurative Cholangitis
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Carcinoma Of Pancreas

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Cancer Of The Pancreas

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Jejunal Somatostatinoma

  • Jejunal Delta Cell Somatostatin Producing Tumor

  • Somatosatinoma Of Jejunum

  • Jejunal Somatostatin-Producing Neuroendocrine Tumor
Cholangitis, Primary Sclerosing

  • Primary Sclerosing Cholangitis

  • PSC

  • Sclerosing Cholangitis

  • Cholangitis, Sclerosing

  • Cholangitis Primary Sclerosing

  • Psc - [Primary Sclerosing Cholangitis]
Chondrodysplasia, Blomstrand Type

  • Chondrodysplasia Blomstrand Type

  • BOCD

  • Blomstrand Lethal Chondrodysplasia

  • Blomstrand Lethal Osteochondrodysplasia

  • Blomstrand'S Lethal Chondrodysplasia

  • Blc

  • Blomstrand Chondrodysplasia

  • Blomstrand Osteochondrodysplasia
Esophageal Adenosquamous Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12568 SCTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11262 GUB021794 Agonist / Unkown
HY-RS12569 Sctr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12570 Sctr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SCTR VGNC VGNC:34370
Macaca mulatta SCTR VGNC VGNC:76996
Felis catus SCTR VGNC VGNC:64937
Mus musculus SCTR MGD MGI:2441720
Rattus norvegicus SCTR RGD RGD:621342
Canis familiaris SCTR VGNC VGNC:45934
Others SCTR NCBI