ZNF10 - zinc finger protein 10 Gene

Also Known as KOX1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7556

About ZNF10

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:133,130,627-133,159,465 (from NCBI)

This gene has 10 transcripts (splice variants), 144 orthologues and 62 paralogues. Broad expression in testis (RPKM 6.7), thyroid (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

ZNF10 Products (1)

mRNA Protein Name
NM_015394.5 NP_056209.2 zinc finger protein 10

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9016654 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
23665872 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17512541 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF10 Protein Structure

KRAB

KRAB: KRAB box (14 - 54)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (279 - 304)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (311 - 331)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (335 - 360)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (364 - 387)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (404 - 415)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (419 - 443)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (447 - 471)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (476 - 498)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (517 - 539)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
Protein Preferred Names Protein Names

zinc finger protein 10

  • zinc finger protein 10 (KOX 1)

ZNF10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF10 P21506 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
ZNF10 P21506 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
ZNF10 P21506 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
ZNF10 P21506 TRIM28 Homo sapiens Q13263
Y2H
9016654
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16097 ZNF10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown