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Cat. No.: HY-115364S

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Parbendazole-d₃

Name: Parbendazole-d3
Brand: MedChemExpress
SKU: HY-115364S
Price: 178.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: SKF 2904-d₃)

Parbendazole-d₃ (SKF 2904-d₃) is the deuterated-labeled Parbendazole (HY-115364). Parbendazole (SKF‑29044) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole is used in research related to acute myeloid leukemia and parasitic infections.

For research use only. We do not sell to patients.

CAS No.: 1613439-58-9
Formula: C₁₃H₁₄D₃N₃O₂
Molecular Weight:250.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Parbendazole-d₃ Chemical Structure

CAS No.: 1613439-58-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[2]^[3]

JNK

β-Tubulin

All Parasite Isoforms :

All JNK Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1613439-58-9
Unlabeled CAS 14255-87-9
Molecular Weight 250.31
Formula C₁₃H₁₄D₃N₃O₂
SMILES

[2H]C([2H])([2H])OC(NC1=NC2=CC(CCCC)=CC=C2N1)=O
Synonyms

SKF 2904-d₃
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matsuo H, et al. Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Communications biology. 2024 Jan 24;7(1):123. [Content Brief]

[2]. Fujita M, et al. Parbendazole induces semaphorin 3A expression via JNK/c-Jun signaling pathway in normal human epidermal keratinocytes. Journal of dermatological science. 2026 May;122(2):47-54.

[3]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. European journal of biochemistry. 1987 Mar 16;163(3):449-55. [Content Brief]

[4]. Al‑Hadiya B M H. Chapter 5‑Parbendazole. In: Profiles of Drug Substances, Excipients and Related Methodology. Vol.35. 2010:263‑284.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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Parbendazole-d₃

All Parasite Isoforms

All JNK Isoforms