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Fatostatin

(Synonyms: 125B11)
55 Cited Publications
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Based on 55 publication(s) in Google Scholar

Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.

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  • Pureté: 99.85%
  • CAS No.: 125256-00-0
  • Formule: C18H18N2S
  • Masse moléculaire:294.41
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Fatostatin Chemical Structure
    Fatostatin Chemical Structure
  • Experimental Validation Results for Fatostatin
  • Experimental Validation Results for Fatostatin
  • Experimental Validation Results for Fatostatin
  • Experimental Validation Results for Fatostatin
  • Experimental Validation Results for Fatostatin
CAS No.: 125256-00-0
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2D/3D Cell Culture and DifferentiationWBCell Proliferation/Viability Assay
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  • Fatostatin Chemical Structure
    Fatostatin Chemical Structure
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    Fatostatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]

    Customer Validation
     Viable cell numbers and PUFA-PC ratio after treatment with LY294002 (iPI3K, 10 µM), Picropodophyllin (iRTK, 10 µM), Ipatasertib (iAkt, 10 µM), or Fatostatin (iSREBP1, 20 µM) for 48 h.

  • 1/16

    Fatostatin purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Sep 26:S1535-6108(24)00350-7. [Abstract]

    Customer Validation
     Representative images of rat mammary organoids treated with Midkine (300 ng/mL), Betulin (5 μM), Fatostatin (5 μM) and Rapamycin (25 nM) for 5 days.

  • 1/16

    Fatostatin purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 Sep 26:S1535-6108(24)00350-7. [Abstract]

    Customer Validation
     Immunoblot showing the expression of MDK, mature SREBF1 (SREBF1 (M)), S6, p-S6(Ser235/236), AKT, p-AKT(Ser473) in the organoids treated with Midkine (300 ng/mL), Betulin (5 μM), Fatostatin (5 μM) and Rapamycin (25 nM) for 5 days. Tubulin serves as loading control.

  • 1/16

    Fatostatin purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

    Customer Validation
     NUPR1 overexpression‐induced lipogenic enzymes expression can be suppressed by co-incubation with Fatostatin (20 μM; 48 h) in MHCC-97H and SK-Hep1 cells.

  • 1/16

    Fatostatin purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

    Customer Validation
     Transwell migration assay. Fatostatin reduces the migration ability of NUPR1-overexpressing MHCC-97H cells.

  • Fatostatin