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NPS-2143

(Synonyms: SB-262470A)
30 Cited Publications
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Based on 30 publication(s) in Google Scholar

NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.

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  • Pureté : 99.94%
  • CAS No.: 284035-33-2
  • Formule: C24H25ClN2O2
  • Masse moléculaire:408.92
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • NPS-2143 Chemical Structure
    NPS-2143 Chemical Structure
  • Experimental Validation Results for NPS-2143
  • Experimental Validation Results for NPS-2143
  • Experimental Validation Results for NPS-2143
CAS No.: 284035-33-2
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  • NPS-2143 Chemical Structure
    NPS-2143 Chemical Structure
    1/16
  • 1/16

    NPS-2143 purchased from MedChemExpress. Usage Cited in: J Vet Sci. 2018 Mar 31;19(2):179-187. [Abstract]

    Customer Validation
     The protein levels of calcium-sensing receptor (CaSR) and its signal molecules regulated by CaSR antagonist NPS 2143. The protein images of CaSR, protein kinase C (PKC), and inositol trisphosphate receptor (IP3R) in the presence of 20 mM tryptophan and NPS 2143.

  • 1/16

    NPS-2143 purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2017:2017:3869561. [Abstract]

    Customer Validation
     N-formyl-Met-Leu-Phe (fMLP; 10 nM) are used to stimulate the cells for 2 min, and the polymorphonuclear neutrophils (PMNs) without fMLP serve as the control. NPS-2143 (100 nM), Cinacalcet (100 nM), and PDTC (100 nM) are added and incubated. Protein expression results are representative of three experiments.

  • 1/16

    NPS-2143 purchased from MedChemExpress. Usage Cited in: Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1309-17. [Abstract]

    Customer Validation
     Distribution of cardioprotective signaling kinases among fractions prepared from perfusion, IPC, and NPS2143-treated IPC hearts. After nondetergent caveolae fractionation via sucrose gradient ultracentrifugation, equal volume of each collected sucrose fraction is subjected to 4–12% SDS-PAGE under reducing condition and followed with p-ERK1/2 (A), p-AKT (B), and p-GSK-3β (C) IB detection. The representative IBs are taken and shown from one out of three independent experiments.

  • NPS-2143