YM17E
Based on 1 Customer Validation
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro.
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- Pureté: 98.34%
- CAS No.: 124900-72-7
- Formule: C40H56N6O2
- Masse moléculaire:652.91
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Lipid Metabolism Compound Library
HY-L091
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Human Metabolite Library
HY-L123
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
Activité biologique
IC50: 44 nM (ACAT in rabbit liver microsomes)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 124900-72-7
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Appearance Solid
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Masse moléculaire 652.91
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Formule C40H56N6O2
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Color White to off-white
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SMILES
O=C(NC1=CC=C(N(C)C)C=C1)N(CC2=CC=CC(CN(C3CCCCCC3)C(NC4=CC=C(N(C)C)C=C4)=O)=C2)C5CCCCCC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : ≥ 125 mg/mL (191.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
YM17E is administered to rats fed an atherogenic diet at intravenous doses of 0, 3, 5 and 10 mg/kg per day for 5 days or oral doses of 0, 3, 10 and 30 mg/kg per day for 5 days. At 2 h after final administration, all the blood and liver are removed. Serum is obtained from the blood by centrifugation and serum total cholesterol and free cholesterol are measured by an enzymatic method. Serum HDL is prepared by the heparin-Mn method.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Uchida T, et al. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats. Atherosclerosis. 1998 Mar;137(1):97-106. [Content Brief]
[2]. Kashiwa M, et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5316 mL | 7.6580 mL | 15.3160 mL | 38.2901 mL |
| 5 mM | 0.3063 mL | 1.5316 mL | 3.0632 mL | 7.6580 mL | |
| 10 mM | 0.1532 mL | 0.7658 mL | 1.5316 mL | 3.8290 mL | |
| 15 mM | 0.1021 mL | 0.5105 mL | 1.0211 mL | 2.5527 mL | |
| 20 mM | 0.0766 mL | 0.3829 mL | 0.7658 mL | 1.9145 mL | |
| 25 mM | 0.0613 mL | 0.3063 mL | 0.6126 mL | 1.5316 mL | |
| 30 mM | 0.0511 mL | 0.2553 mL | 0.5105 mL | 1.2763 mL | |
| 40 mM | 0.0383 mL | 0.1915 mL | 0.3829 mL | 0.9573 mL | |
| 50 mM | 0.0306 mL | 0.1532 mL | 0.3063 mL | 0.7658 mL | |
| 60 mM | 0.0255 mL | 0.1276 mL | 0.2553 mL | 0.6382 mL | |
| 80 mM | 0.0191 mL | 0.0957 mL | 0.1915 mL | 0.4786 mL | |
| 100 mM | 0.0153 mL | 0.0766 mL | 0.1532 mL | 0.3829 mL |
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