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Anifrolumab

(Synonyms: MDX-1333; MEDI-546)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research.

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  • Pureté: 99.79%
  • CAS No.: 1326232-46-5
  • Masse moléculaire:144.92 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Experimental Validation Results for Anifrolumab
  • Anifrolumab Chemical Structure
    Anifrolumab Chemical Structure
CAS No.: 1326232-46-5
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609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IFNAR1 Protein, Human (HEK293, His, HY-P70483) can bind Anifrolumab. The EC50 for this effect is 21.2 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 U937 cells with Anifrolumab (HY-P99168, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.

  • 1/16

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 26;15(1):7165. [Abstract]

    Customer Validation
     Anifrolumab (10 µg/ml, 2 h) suppressed PDCD1 gene expression in A2058 human melanoma cells.

  • 1/16

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 26;15(1):7165. [Abstract]

    Customer Validation
     Anifrolumab (10 µg/ml, 2 h) suppressed IFN-α-dependent PD-1 expression in A2058 human melanoma cells.

  • 1/16

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762. [Abstract]

    Customer Validation
     Anifrolumab (1 or 10 µg/ml) reversed the H/R‑induced increase in the secretion of type I IFNs (including IFN‑α and IFN‑β) into the culture medium of ventricular cardiac organoids and co‑cultured THP‑1 cells.

  • 1/16

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762. [Abstract]

    Customer Validation
     Anifrolumab (1 or 10 µg/ml) downregulated the expression of type I IFN-related genes in ventricular cardiac organoids and co‑cultured THP‑1 cells.

  • 1/16

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762. [Abstract]

    Customer Validation
     Anifrolumab (1 or 10 µg/ml) decreased the H/R‑induced proportion of CD86+ cells and the mean fluorescence intensity of CD86 protein in ventricular cardiac organoids and co-cultured THP-1 cells.

  • Anifrolumab Chemical Structure
    1/16
  • Anifrolumab
  • Immobilized IFNAR1 Protein, Human (HEK293, His, HY-P70483) can bind Anifrolumab. The EC50 for this effect is 21.2 ng/mL.
  • Flow cytometric analysis of 1.5X106 U937 cells with Anifrolumab (HY-P99168, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.