Apraclonidine
Based on 3 publication(s) in Google Scholar
Apraclonidine (ALO 2145 (free base)), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 66711-21-5
- Formule: C9H10Cl2N4
- Masse moléculaire:245.11
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Apraclonidine
MoreVoir tous les produits spécifiques à Isoform Adrenergic Receptor
More
Activité biologique
|
α adrenergic receptor |
Apraclonidine (ALO 2145 (free base)) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:male rabbits[3]
-
Dosage:1.15%
-
Administration:Apraclonidine (1.15%, single instillation)
-
Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 66711-21-5
-
Masse moléculaire 245.11
-
Formule C9H10Cl2N4
-
SMILES
NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1
-
Synonyms
ALO 2145 free base
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Anal Chim Acta
Bifunctional Ti4+-modified paper for selective extraction or removal of phospholipids and paper spray mass spectrometry for bioanalysis in urine and plasma. [Abstract]2023 Oct 16:1278:341673. PMID: 37709425 -
-
Pureté et documentation
Références
[1]. Subhashie Wijemanne, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci [Content Brief]
[2]. R V Searles, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999 Apr;58(4):220-6. [Content Brief]
[3]. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apraclonidine Related Classifications
HY-12720 Related Classifications
Powered by Bioz