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Cat. No.: HY-150252

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ATIC-IN-1

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a K_i value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates.

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CAS No.: 1402453-15-9
Formule: C₂₁H₃₃N₇O₅
Masse moléculaire:463.53

Stockage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ATIC-IN-1 Chemical Structure

CAS No.: 1402453-15-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)^[1]

In Vitro

ATIC-IN-1 (10 μM, 50 μM) is a specific inhibitor, and shows nonspecific aggregate mechanism in the present of 1 mg/mL and 10 mg/mL BSA^[1].
ATIC-IN-1 (100-500 μM; 48 h) inhibits the proliferation of MCF-7 cells^[1].
ATIC-IN-1 (250 μM; 24-72 h) results the reduction of division rather than leads to cell death increase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7 cells
Concentration:

100 μM, 250 μM, 500 μM
Incubation Time:

0 h, 24 h, 48 h, and 72 h
Result:

Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.

Chemical Information

CAS No. 1402453-15-9
Appearance Solid
Masse moléculaire 463.53
Formule C₂₁H₃₃N₇O₅
Color White to off-white
SMILES

N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Am J Physiol Cell Physiol

Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. [Abstract]

2025 Nov 1;329(5):C1560-C1576. PMID: 41071646

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
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MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13(11):1628-34. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ATIC-IN-1

1 Cited Publications

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ATIC-IN-1

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