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Cat. No.: HY-107420S

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AY 9944-d₈

AY 9944-d₈ is the deuterium labeled AY 9944 (HY-107420). AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC₅₀ of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.

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Formule: C₂₂H₂₂D₈Cl₄N₂
Masse moléculaire:472.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AY 9944-d₈ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Application
Chemical Information
Pureté et documentation
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 366-93-8
Masse moléculaire 472.35
Formule C₂₂H₂₂D₈Cl₄N₂
SMILES

ClC(C([2H])=C([2H])C([2H])=C1[2H])=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C([2H])=C([2H])C([2H])=C3[2H])Cl.Cl.Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.