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BIIB021 mesylate

(Synonyms: CNF2024 mesylate)
4 Cited Publications
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Based on 4 publication(s) in Google Scholar

BIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML.

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  • CAS No.: 1225041-97-3
  • Formule: C15H19ClN6O4S
  • Masse moléculaire:414.87
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  • BIIB021 mesylate Chemical Structure
    BIIB021 mesylate Chemical Structure
  • Experimental Validation Results for BIIB021 mesylate
  • Experimental Validation Results for BIIB021 mesylate
CAS No.: 1225041-97-3
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  • BIIB021 mesylate Chemical Structure
    BIIB021 mesylate Chemical Structure
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    BIIB021 mesylate purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2024 Apr 29;17(5):569. [Abstract]

    Customer Validation
     Dose–response curve of PC3 after BIIB021 (CNF2024) treatment for 48 h, respectively, in either normal-glucose or low-glucose media. Abbreviations: CM: conditional media; ECAR: extracellular acidification rate.

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    BIIB021 mesylate purchased from MedChemExpress. Usage Cited in: Viruses. 2021 Apr 2;13(4):610. [Abstract]

    Customer Validation
     Vero cells were treated with the indicated concentration of BIIB021 (0.0001-10 μM). Images were taken 2 days (up panels), or 3 days (down panels) after infection with SARS-CoV-2 at an MOI of 0.03. CPE Scores (blue) and TOX Scores (red) were determined by ‘CPETOXnet’ and are shown in a concentration dependent manner (n = 4).

  • BIIB021 mesylate