CNBCA
CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study.
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- CAS No.: 3044817-00-4
- Formule: C26H34O5
- Masse moléculaire:426.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
0.87 μM (SHP2)[1]
CNBCA (0.25, 0.50, 1, 2 μM, 48 h) inhibits SHP2 mediated Akt and ERK1/2 activation in the BT474 and MDA-MB468 cells with an approximate IC50 of 1.0 μM[1].
CNBCA (500 nM, 24-72 h) inhibits cell growth in the BT474 and MDA-MB468 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT474 and MDA-MB468 cells
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Concentration:0.25, 0.50, 1, 2 μM
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Incubation Time:48 h
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Result:Inhibited SHP2 mediated Akt and ERK1/2 activation.
Chemical Information
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CAS No. 3044817-00-4
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Masse moléculaire 426.55
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Formule C26H34O5
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SMILES
OC(CCCC1=C(OCCCCCCCCC)C=CC(C2=CC=C(C(O)=O)C=C2)=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CNBCA Related Classifications
HY-155098 Related Classifications
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