EP9
Based on 1 Customer Validation
EP9 is a peptide targeting CD63. EP9 binds specifically to the extracellular region of CD63, including a groove in the large extracellular loop (EC2) or the extracellular end of CD63’s central cavity, triggering endocytosis of decorated nanoemulsions/liposomes into cells. EP9 promotes cellular uptake of decorated nanoemulsions/liposomes into activated cardiac fibroblasts and epicardial stromal cells via caveolae and/or clathrin-coated pits. EP9 can be used for the research of myocardial infarction, cardiac fibrosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.84%
- Formule: C56H100N18O13S2
- Masse moléculaire:1297.64
-
Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Anti-Cardiovascular Disease Compound Library
HY-L046
-
Peptide Library
HY-L105
-
Extracellular Vesicles (EVs) Compound Library
HY-L168
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Immunology/Inflammation Compound Library
HY-L007
-
Peptide Compound Library
HY-L105S
Activité biologique
EP9 (5 µg; 30 min) binds specifically to mouse cardiac fibroblasts and EpiSC, human primary cardiac fibroblasts, and normal human dermal fibroblasts, with the highest binding affinity for mouse EpiSC and human primary cardiac fibroblasts[1].
EP9 (1 mM; 1 h) specifically binds to the tetraspanin CD63, a transmembrane protein on the surface of normal human dermal fibroblasts, as confirmed by significant enrichment in EP9 probe samples relative to control MUT probe samples[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (male, 8-12 weeks old, 20-25 g, myocardial infarction induced by 50 min left anterior descending coronary artery ligation followed by reperfusion)[1]
-
Dosage:25 µg EP9 per 100 µL PFC-NE; 150 µL EP9-PFC-NE
-
Administration:i.v.; single dose
-
Result:Localized a strong 19F signal specifically to the infarcted anterior wall of the left ventricle on in vivo MRI, with a signal-to-noise ratio significantly higher than that of the mutated peptide control.
Declined plasma 19F signal with a half-life of ~20 hours.
Showed a transmural 19F signal in the infarcted area that increased between 12 hours and 24 hours post-injection via ex vivo MRI.
Revealed EP9-PFC-NE uptake primarily by cardiac fibroblasts and epicardial stromal cells, with no detectable uptake in macrophages, cardiomyocytes, or endothelial cells via transmission electron microscopy.
Demonstrated intracellular particles had an average size of 118 nm, matching the pre-injection particle size of 124 nm.
Chemical Information
-
Appearance Solid
-
Masse moléculaire 1297.64
-
Formule C56H100N18O13S2
-
Color White to off-white
-
Sequence
Ac-Lys-Leu-Met-Leu-Pro-Arg-Pro-Gly-Gly-Gly-Lys-Cys-NH2
-
Sequence Shortening
Ac-KLMLPRPGGGKC-NH2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 100 mg/mL (77.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (278 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7706 mL | 3.8531 mL | 7.7063 mL | 19.2657 mL |
| 5 mM | 0.1541 mL | 0.7706 mL | 1.5413 mL | 3.8531 mL | |
| 10 mM | 0.0771 mL | 0.3853 mL | 0.7706 mL | 1.9266 mL | |
| 15 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2844 mL | |
| 20 mM | 0.0385 mL | 0.1927 mL | 0.3853 mL | 0.9633 mL | |
| 25 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7706 mL | |
| 30 mM | 0.0257 mL | 0.1284 mL | 0.2569 mL | 0.6422 mL | |
| 40 mM | 0.0193 mL | 0.0963 mL | 0.1927 mL | 0.4816 mL | |
| 50 mM | 0.0154 mL | 0.0771 mL | 0.1541 mL | 0.3853 mL | |
| 60 mM | 0.0128 mL | 0.0642 mL | 0.1284 mL | 0.3211 mL |
EP9 Related Classifications
HY-P11797 Related Classifications
Powered by Bioz