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CDX4 - caudal type homeobox 4 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1046

About CDX4

Cytogenetic location: Xq13.2 Genomic coordinates (GRCh38): X:73,447,053-73,455,171 (from NCBI)

This gene has 1 transcript (splice variant), 96 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012]

CDX4 Products (1)

mRNA	Protein	Name
NM_005193.2	NP_005184.1	homeobox protein CDX-4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21471217	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	21471217	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21471217	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21471217	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21471217	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDX4 Protein Structure

Caudal_act

Homeobox

0
100
200
284 a.a.

Protein Preferred Names	Protein Names
homeobox protein CDX-4	caudal type homeobox transcription factor 4

CDX4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CDX4	O14627	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	CDX4	O14627	PRKAB2	Homo sapiens	O43741	Y2H Array	31515488
Intra	CDX4	O14627	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	CDX4	O14627	PRKAA2	Homo sapiens	P54646	Validated Y2H	32296183
Intra	CDX4	O14627	CKS1B	Homo sapiens	P61024	Validated Y2H	25416956
Intra	CDX4	O14627	CKS1B	Homo sapiens	P61024	Y2H Prey Pooling	25416956
Intra	CDX4	O14627	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	CDX4	O14627	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	CDX4	O14627	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	CDX4	O14627	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
Intra	CDX4	O14627	LMO1	Homo sapiens	P25800	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Renpenning Syndrome 1	Renpenning Syndrome Golabi-Ito-Hall Syndrome Mrxs3 Mrxs8 X-Linked Intellectual Disability Due To Pqbp1 Mutations RENS1 Sutherland-Haan X-Linked Mental Retardation Syndrome Shs Mrx55 X-Linked Intellectual Disability, Renpenning Type Sutherland-Haan Syndrome Mental Retardation, X-Linked, Renpenning Type Mental Retardation, X-Linked, With Spastic Diplegia Mental Retardation, X-Linked, Syndromic 3 Mental Retardation, X-Linked, Syndromic 8 Mental Retardation, X-Linked 55 Syndromic X-Linked Mental Retardation 8 X-Linked Mental Retardation Renpenning Type X-Linked Mental Retardation With Spastic Diplegia Sutherland-Haan X-Linked Intellectual Disability Syndrome X-Linked Intellectual Disability With Spastic Diplegia Hamel Cerebropalatocardiac Syndrome Porteous Syndrome X-Linked Intellectual Deficit Due To Pqbp1 Mutations X-Linked Intellectual Deficit, Renpenning Type X-Linked Intellectual Disability, Sutherland-Haan Type Hamel Cerebro-Palato-Cardiac Syndrome Renpenning Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS02431	CDX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDX4	VGNC	VGNC:27159
Mus musculus	CDX4	MGD	MGI:88362
Macaca mulatta	CDX4	VGNC	VGNC:70997
Canis familiaris	CDX4	VGNC	VGNC:39086
Rattus norvegicus	CDX4	RGD	RGD:1561529
Others	CDX4	NCBI