SLC34A2 - solute carrier family 34 member 2 Gene

Also Known as PULAM; NPTIIb; NAPI-3B; NAPI-IIb

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10568

About SLC34A2

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,655,851-25,678,748 (from NCBI)

This gene has 7 transcripts (splice variants), 296 orthologues, 2 paralogues and is associated with 75 phenotypes. Restricted expression toward lung (RPKM 380.9).

Summary

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

SLC34A2 Products (3)

mRNA	Protein	Name
NM_001177998.2	NP_001171469.2	sodium-dependent phosphate transport protein 2B isoform b
NM_001177999.2	NP_001171470.2	sodium-dependent phosphate transport protein 2B isoform b
NM_006424.3	NP_006415.3	sodium-dependent phosphate transport protein 2B isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables phosphate ion binding	IDA IDA: Inferred from direct assay	12488042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sodium ion binding	IDA IDA: Inferred from direct assay	12488042	GOA
enables sodium:phosphate symporter activity	IDA IDA: Inferred from direct assay	10329428	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in intracellular phosphate ion homeostasis	IDA IDA: Inferred from direct assay	10610722	GOA
involved in phosphate ion transport	IDA IDA: Inferred from direct assay	10329428	GOA
involved in response to estrogen	IEP IEP: Inferred from expression pattern	12893629	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15970207	GOA
located in membrane	IDA IDA: Inferred from direct assay	10329428	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC34A2 Protein Structure

Na_Pi_cotrans

0
200
400
600
690 a.a.

Protein Preferred Names	Protein Names
sodium-dependent phosphate transport protein 2B	sodium/phosphate cotransporter 2B

SLC34A2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81437	SLC34A2 Antibody (YA1182)	IHC-P	Human
HY-P81437A	SLC34A2 Antibody (YA1182)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Pulmonary Alveolar Microlithiasis	PULAM Pam
Testicular Microlithiasis
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Baritosis	Deposition Of Barium In The Lungs Inhalation Of Barytes
Pulmonary Hemosiderosis	Idiopathic Pulmonary Hemosiderosis Alveolar Hypoventilation Syndrome Brown Induration Brown Lung Siderosis Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin Byssinosis
Hypophosphatemic Rickets With Hypercalciuria, Hereditary	Hereditary Hypophosphatemic Rickets With Hypercalciuria HHRH Hypophosphatemic Rickets With Hypercalciuria Hypercalciuric Rickets
Chronic Congestive Splenomegaly
Secondary Hypertrophic Osteoarthropathy	Osteoarthropathy, Secondary Hypertrophic Bamberger-Marie Disease Hpoa - Hypertrophic Pulmonary Osteoarthropathy Hypertrophic Pulmonary Osteoarthropathy Marie Bamberger Disease
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Hyperlipoproteinemia, Type V	Hyperlipoproteinemia Type V Hyperchylomicronemia, Late-Onset Familial Type 5 Hyperlipoproteinemia Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial Hyperlipidemia, Type V Hyperlipemia, Mixed Hyperlipemia, Combined Fat And Carbohydrate-Induced Familial Hyperlipoproteinemia Type V Fredrickson Type V Lipaemia Hyperlipoproteinemia Type 5 Hyperchylomicronemia Late Onset Hyperlipemia Combined Fat And Carbohydrate-Induced Hyperlipemia Mixed Hyperlipidemia Type V Mixed Hyperlipemia Type V Hyperlipoproteinemia Hyperlipoproteinemia 5 HLPP5 Hyperlipidemia, Familial Combined Mixed Hyperlipidemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-145894	NaPi2b-IN-2	Inhibitor	99.02%	Unkown
HY-146429	NaPi2b-IN-3	Inhibitor	/	Unkown
HY-171735	Anti-SLC34A2 (Lifastuzumab)-SMCC-DM1		/	Unkown
HY-171736	Anti-SLC34A2 (Lifastuzumab)-SPDB-DM4		/	Unkown
HY-171737	Anti-SLC34A2 (Lifastuzumab)-McMMAF		/	Unkown
HY-171738	Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38		/	Unkown
HY-RS13193	SLC34A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17389	Slc34a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23844	Slc34a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC34A2	VGNC	VGNC:34818
Felis catus	SLC34A2	VGNC	VGNC:65317
Macaca mulatta	SLC34A2	VGNC	VGNC:77459
Mus musculus	SLC34A2	MGD	MGI:1342284
Rattus norvegicus	SLC34A2	RGD	RGD:620889
Canis familiaris	SLC34A2	VGNC	VGNC:46359
Others	SLC34A2	NCBI