EPB41L2 - erythrocyte membrane protein band 4.1 like 2 Gene

Also Known as 4.1G; 4.1-G

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2037

About EPB41L2

Cytogenetic location: 6q23.1-q23.2 Genomic coordinates (GRCh38): 6:130,839,347-131,063,245 (from NCBI)

This gene has 34 transcripts (splice variants), 230 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 33.9), ovary (RPKM 23.5) and 23 other tissues.

Summary

Predicted to enable PH domain binding activity; cytoskeletal protein binding activity; and structural molecule activity. Involved in positive regulation of protein localization to cell cortex. Located in cell junction; nucleoplasm; and plasma membrane. Colocalizes with COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

EPB41L2 Products (22)

mRNA Protein Name
NM_001135554.2 NP_001129026.1 band 4.1-like protein 2 isoform b
NM_001135555.4 NP_001129027.1 band 4.1-like protein 2 isoform b
NM_001199388.3 NP_001186317.1 band 4.1-like protein 2 isoform c
NM_001252660.2 NP_001239589.1 band 4.1-like protein 2 isoform d
NM_001350299.2 NP_001337228.1 band 4.1-like protein 2 isoform e
NM_001350301.2 NP_001337230.1 band 4.1-like protein 2 isoform f
NM_001350302.2 NP_001337231.1 band 4.1-like protein 2 isoform a
NM_001350303.2 NP_001337232.1 band 4.1-like protein 2 isoform g
NM_001350304.2 NP_001337233.1 band 4.1-like protein 2 isoform h
NM_001350305.2 NP_001337234.1 band 4.1-like protein 2 isoform h
NM_001350306.2 NP_001337235.1 band 4.1-like protein 2 isoform h
NM_001350307.2 NP_001337236.1 band 4.1-like protein 2 isoform i
NM_001350308.2 NP_001337237.1 band 4.1-like protein 2 isoform c
NM_001350309.1 NP_001337238.1 band 4.1-like protein 2 isoform c
NM_001350310.2 NP_001337239.1 band 4.1-like protein 2 isoform c
NM_001350311.2 NP_001337240.1 band 4.1-like protein 2 isoform d
NM_001350312.2 NP_001337241.1 band 4.1-like protein 2 isoform d
NM_001350313.2 NP_001337242.1 band 4.1-like protein 2 isoform d
NM_001350314.2 NP_001337243.1 band 4.1-like protein 2 isoform j
NM_001350315.2 NP_001337244.1 band 4.1-like protein 2 isoform j
NM_001350320.2 NP_001337249.1 band 4.1-like protein 2 isoform k
NM_001431.4 NP_001422.1 band 4.1-like protein 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of protein localization to cell cortex IMP
IMP: Inferred from mutant phenotype
23870127 GOA
Cellular Component GO Annotation Evidence Références Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
located in cell cortex IDA
IDA: Inferred from direct assay
23870127 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPB41L2 Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (222 - 298)

FERM_M

FERM_M: FERM central domain (300 - 409)

FERM_C

FERM_C: FERM C-terminal PH-like domain (413 - 501)

FA

FA: FERM adjacent (FA) (507 - 550)

SAB

SAB: SAB domain (630 - 677)

4_1_CTD

4_1_CTD: 4.1 protein C-terminal domain (CTD) (887 - 999)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1005 a.a.
Protein Preferred Names Protein Names

band 4.1-like protein 2

  • erythrocyte membrane protein band 4.1 like-protein 2

EPB41L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
EPB41L2 O43491 FCGR1A Homo sapiens P12314
Anti Bait CoIP
22003208
Intra
EPB41L2 O43491 FCGR1A Homo sapiens P12314
Pull Down
22003208
Intra
EPB41L2 O43491 FCGR1A Homo sapiens P12314
IF
22003208
Intra
EPB41L2 O43491 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
EPB41L2 O43491 YWHAG Homo sapiens P61981
Y2H Pooling
20936779
Intra
EPB41L2 O43491 YWHAG Homo sapiens P61981
Anti Tag CoIP
33961781
Intra
EPB41L2 O43491 YWHAG Homo sapiens P61981
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Petrous Apex Meningioma

  • Meningioma Of The Petrous Ridge
Cellular Congenital Mesoblastic Nephroma
Tuberculum Sellae Meningioma

  • Meningioma Of The Tuberculum Sellae
Sella Turcica Neoplasm

  • Tumor Of Sella Turcica
Cerebellopontine Angle Meningioma

  • Meningioma Of The Cerebellar Pontine Angle
Hereditary Elliptocytosis

  • Congenital Elliptocytosis

  • Ovalocytosis

  • Elliptocytosis, Hereditary

  • He

  • Elliptocytosis Hereditary

  • Congenital Ovalocytosis

  • Elliptocytosis

  • Hereditary Elliptocytosis With Infantile Poikilocytosis

  • Hereditary Ovalocytosis

  • Oval Erythrocytosis

  • He - [Hereditary Elliptocytosis]

  • Elliptocytosis Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04412 EPB41L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EPB41L2 RGD RGD:1563977
Mus musculus EPB41L2 MGD MGI:103009
Macaca mulatta EPB41L2 VGNC VGNC:72232
Bos taurus EPB41L2 VGNC VGNC:28521
Felis catus EPB41L2 VGNC VGNC:61893
Canis familiaris EPB41L2 VGNC VGNC:40394
Others EPB41L2 NCBI