EPB41L3 - erythrocyte membrane protein band 4.1 like 3 Gene

Also Known as 4.1B; DAL1; DAL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23136

About EPB41L3

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:5,392,386-5,630,663 (from NCBI)

This gene has 36 transcripts (splice variants), 289 orthologues and 10 paralogues. Broad expression in brain (RPKM 28.0), testis (RPKM 24.6) and 21 other tissues.

Summary

Predicted to enable cytoskeletal protein-membrane anchor activity. Predicted to be a structural constituent of Cytoskeleton. Predicted to be involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to paranode region of axon. Located in cell-cell junction and plasma membrane. Biomarker of meningioma. [provided by Alliance of Genome Resources, Apr 2022]

EPB41L3 Products (30)

mRNA	Protein	Name
NM_001281533.2	NP_001268462.1	band 4.1-like protein 3 isoform 2
NM_001281534.3	NP_001268463.1	band 4.1-like protein 3 isoform 3
NM_001281535.2	NP_001268464.1	band 4.1-like protein 3 isoform 4
NM_001330557.2	NP_001317486.1	band 4.1-like protein 3 isoform 5
NM_001384682.1	NP_001371611.1	band 4.1-like protein 3 isoform 2
NM_001384683.1	NP_001371612.1	band 4.1-like protein 3 isoform 4
NM_001384684.1	NP_001371613.1	band 4.1-like protein 3 isoform 5
NM_001384685.1	NP_001371614.1	band 4.1-like protein 3 isoform 6
NM_001384686.1	NP_001371615.1	band 4.1-like protein 3 isoform 7
NM_001384687.1	NP_001371616.1	band 4.1-like protein 3 isoform 8
NM_001384688.1	NP_001371617.1	band 4.1-like protein 3 isoform 8
NM_001384689.1	NP_001371618.1	band 4.1-like protein 3 isoform 9
NM_001384690.1	NP_001371619.1	band 4.1-like protein 3 isoform 9
NM_001384691.1	NP_001371620.1	band 4.1-like protein 3 isoform 10
NM_001384692.1	NP_001371621.1	band 4.1-like protein 3 isoform 11
NM_001384693.1	NP_001371622.1	band 4.1-like protein 3 isoform 12
NM_001384694.1	NP_001371623.1	band 4.1-like protein 3 isoform 13
NM_001384695.1	NP_001371624.1	band 4.1-like protein 3 isoform 14
NM_001384696.1	NP_001371625.1	band 4.1-like protein 3 isoform 15
NM_001384697.1	NP_001371626.1	band 4.1-like protein 3 isoform 16
NM_001384698.1	NP_001371627.1	band 4.1-like protein 3 isoform 17
NM_001384699.1	NP_001371628.1	band 4.1-like protein 3 isoform 18
NM_001384700.1	NP_001371629.1	band 4.1-like protein 3 isoform 19
NM_001384701.1	NP_001371630.1	band 4.1-like protein 3 isoform 20
NM_001384702.1	NP_001371631.1	band 4.1-like protein 3 isoform 21
NM_001384703.1	NP_001371632.1	band 4.1-like protein 3 isoform 22
NM_001384704.1	NP_001371633.1	band 4.1-like protein 3 isoform 23
NM_001384705.1	NP_001371634.1	band 4.1-like protein 3 isoform 24
NM_001384706.1	NP_001371635.1	band 4.1-like protein 3 isoform 25
NM_012307.5	NP_036439.2	band 4.1-like protein 3 isoform 1

EPB41L3 Protein Structure

FERM_N

FERM_M

FERM_C

SAB

4_1_CTD

0
200
400
600
800
1000
1087 a.a.

Protein Preferred Names	Protein Names
band 4.1-like protein 3	differentially expressed in adenocarcinoma of the lung protein 1

EPB41L3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	EPB41L3	Q9Y2J2	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	EPB41L3	Q9Y2J2	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	EPB41L3	Q9Y2J2	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	24366813
Intra	EPB41L3	Q9Y2J2	YWHAG	Homo sapiens	P61981	Y2H Pooling	20936779
Intra	EPB41L3	Q9Y2J2	YWHAG	Homo sapiens	P61981	Anti Bait CoIP	17353931

Cross: Cross-species interaction Intra: Intraspecies interaction

EPB41L3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P89583	4.1B Antibody (YA8927)	WB, ELISA	human

Related Diseases

Diseases	Alias
Benign Meningioma	Meningioma, Benign
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Bejel	Njovera Dichuchwa Nonvenereal Endemic Syphilis Endemic Syphilis Frenga Nonvenereal Syphilis Treponemal Infections Non-Venereal Endemic Syphilis Siti Skerljevo Belesh
Yaws	Frambesia Frambesia Tropica Bouba Frambosie Polypapilloma Tropicum Thymosis Endemic Treponematoses Treponema Pertenue Infection Pian Framboesia Framboesia Tropica Castellani Infection By Treponema Pertenue Parangi Framboesioma Chancre Of Yaws Primary Framboesia Initial Lesions Of Yaws Mother Yaw Initial Framboesia
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Gummatous Syphilis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Secondary Syphilis	Syphilis, Secondary Secondary Syphilis Of Viscera Or Bone
Congenital Syphilis	Syphilis, Congenital Congenital Syphilis, Unspecified Mtct Of Syphilis Mother-To-Child Transmission Of Syphilis Syphilis Congenital Hereditary Syphilis Heredosyphilis
Osteogenesis Imperfecta, Type Xiii	Osteogenesis Imperfecta Type 13 OI13 Osteogenesis Imperfecta Type Xiii Oi, Type Xiii Osteogenesis Imperfecta 13 Oi Type Xiii Oi-Xiii
Childhood Meningioma	Pediatric Meningioma
Primary Syphilis	Early Symptomatic Syphilis Early Syphilis, Symptomatic Symptomatic Early Syphilis
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04413	EPB41L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EPB41L3	VGNC	VGNC:61894
Macaca mulatta	EPB41L3	VGNC	VGNC:72233
Bos taurus	EPB41L3	VGNC	VGNC:28522
Rattus norvegicus	EPB41L3	RGD	RGD:71089
Mus musculus	EPB41L3	MGD	MGI:103008
Canis familiaris	EPB41L3	VGNC	VGNC:40395
Others	EPB41L3	NCBI