BRMS1 - BRMS1 transcriptional repressor and anoikis regulator Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25855

About BRMS1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,337,339-66,345,104 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues.

Summary

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast Cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

BRMS1 Products (2)

mRNA Protein Name
NM_001024957.2 NP_001020128.1 breast cancer metastasis-suppressor 1 isoform 2
NM_015399.4 NP_056214.1 breast cancer metastasis-suppressor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables NF-kappaB binding IDA
IDA: Inferred from direct assay
17000776 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16919237 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20830743 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
17000776 GOA
involved in positive regulation of anoikis IMP
IMP: Inferred from mutant phenotype
17000776 GOA
involved in positive regulation of protein deacetylation IDA
IDA: Inferred from direct assay
17000776 GOA
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
17000776 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20830743 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17000776 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRMS1 Protein Structure

Sds3

Sds3: Sds3-like (58 - 229)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

breast cancer metastasis-suppressor 1

  • breast cancer metastasis suppressor 1

BRMS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
BRMS1 Q9HCU9 DNAJB6 Homo sapiens O75190
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 DNAJB6 Homo sapiens O75190
Y2H
16919237
Intra
BRMS1 Q9HCU9 HDAC6 Homo sapiens Q9UBN7
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 HDAC6 Homo sapiens Q9UBN7
Anti Tag CoIP
16919237
Intra
BRMS1 Q9HCU9 HDAC2 Homo sapiens Q92769
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
33961781
Intra
BRMS1 Q9HCU9 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
28514442
Intra
BRMS1 Q9HCU9 HDAC1 Homo sapiens Q13547
Anti Tag CoIP
16919237
Intra
BRMS1 Q9HCU9 HDAC4 Homo sapiens P56524
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 NMI Homo sapiens Q13287
Validated Y2H
25416956
Intra
BRMS1 Q9HCU9 NMI Homo sapiens Q13287
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 NMI Homo sapiens Q13287
Y2H
16919237
Intra
BRMS1 Q9HCU9 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra
BRMS1 Q9HCU9 NMI Homo sapiens Q13287
MAPPIT
25416956
Intra
BRMS1 Q9HCU9 SMARCE1 Homo sapiens Q969G3
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 SMARCE1 Homo sapiens Q969G3
Anti Tag CoIP
25416956
Intra
BRMS1 Q9HCU9 SUDS3 Homo sapiens Q9H7L9
Y2H
16919237
Intra
BRMS1 Q9HCU9 SUDS3 Homo sapiens Q9H7L9
Anti Bait CoIP
16919237
Intra
BRMS1 Q9HCU9 HDAC5 Homo sapiens Q9UQL6
Anti Tag CoIP
16919237
Intra
BRMS1 Q9HCU9 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-144896 FHT-1015 Inhibitor 98.41% Unkown
HY-145946 BRM/BRG1 ATP Inhibitor-2 Inhibitor 99.67% Unkown
HY-148373 BRM/BRG1 ATP Inhibitor-3 Inhibitor / Unkown
HY-148374 BRM/BRG1 ATP Inhibitor-4 Inhibitor / Unkown
HY-178481 BRM/BRG1 ATP-IN-5 Inhibitor / Unkown
HY-178484 BRM/BRG1 ATP-IN-6 Inhibitor / Unkown
HY-178490 BRM/BRG1 ATP-IN-8 Inhibitor / Unkown
HY-180428 BRM/BRG1 ATP degrader-1 Degrader / Unkown
HY-183939 L1-CIDE-BRM1-13 / Unkown
HY-RS01626 BRMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22408 Brms1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28932 Brms1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BRMS1 VGNC VGNC:60178
Canis familiaris BRMS1 VGNC VGNC:54777
Bos taurus BRMS1 VGNC VGNC:54781
Rattus norvegicus BRMS1 RGD RGD:1311057
Mus musculus BRMS1 MGD MGI:2388804
Macaca mulatta BRMS1 VGNC VGNC:70334
Others BRMS1 NCBI