HOXB7 - homeobox B7 Gene

Also Known as HOX2; HOX2C; HHO.C1; Hox-2.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3217

About HOXB7

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,607,232-48,611,017 (from NCBI)

This gene has 3 transcripts (splice variants), 166 orthologues and 42 paralogues. Broad expression in kidney (RPKM 10.0), colon (RPKM 8.7) and 15 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

HOXB7 Products (1)

mRNA Protein Name
NM_004502.4 NP_004493.3 homeobox protein Hox-B7

HOXB7 Protein Structure

Homeobox

Homeobox: Homeobox domain (138 - 194)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B7

  • homeo box 2C

HOXB7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
HOXB7 P09629 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
HOXB7 P09629 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
HOXB7 P09629 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
HOXB7 P09629 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
HOXB7 P09629 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
HOXB7 P09629 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
HOXB7 P09629 PRKDC Homo sapiens P78527
Pull Down
17308091
Intra
HOXB7 P09629 PRKDC Homo sapiens P78527
Anti Bait CoIP
17308091
Intra
HOXB7 P09629 XRCC5 Homo sapiens P13010
Pull Down
17308091
Intra
HOXB7 P09629 XRCC5 Homo sapiens P13010
Anti Tag CoIP
17308091
Intra
HOXB7 P09629 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
HOXB7 P09629 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
HOXB7 P09629 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
HOXB7 P09629 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra
HOXB7 P09629 CLK3 Homo sapiens P49761
Y2H Array
25416956
Intra
HOXB7 P09629 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra
HOXB7 P09629 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Renal Hypoplasia
Bilateral Renal Aplasia
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Hydronephrosis

  • Stricture Of Ureteropelvic Junction With Hydronephrosis

  • Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P5930 HOXB7 8–25 / Unkown
HY-RS06311 HOXB7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20036 Hoxb7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26539 Hoxb7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HOXB7 VGNC VGNC:104621
Mus musculus HOXB7 MGD MGI:96188
Bos taurus HOXB7 VGNC VGNC:29921
Canis familiaris HOXB7 VGNC VGNC:41753
Rattus norvegicus HOXB7 RGD RGD:1559918
Felis catus HOXB7 VGNC VGNC:67624
Others HOXB7 NCBI