NPR1 - natriuretic peptide receptor 1 Gene

Also Known as ANPa; NPRA; ANPRA; GUC2A; GUCY2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4881

About NPR1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,678,688-153,693,992 (from NCBI)

This gene has 3 transcripts (splice variants), 185 orthologues and 17 paralogues. Biased expression in fat (RPKM 49.0), lung (RPKM 10.4) and 9 other tissues.

Summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound Guanylate Cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

NPR1 Products (1)

mRNA	Protein	Name
NM_000906.4	NP_000897.3	atrial natriuretic peptide receptor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables guanylate cyclase activity	IDA IDA: Inferred from direct assay	1672777	GOA
enables hormone binding	IPI IPI: Inferred from physical interaction	12547834	GOA
enables natriuretic peptide receptor activity	IDA IDA: Inferred from direct assay	1660465	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	1660465	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cGMP biosynthetic process	IDA IDA: Inferred from direct assay	1672777	GOA
involved in receptor guanylyl cyclase signaling pathway	IDA IDA: Inferred from direct assay	1672777	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPR1 Protein Structure

ANF_receptor

Pkinase_Tyr

Guanylate_cyc

0
200
400
600
800
1000
1061 a.a.

Protein Preferred Names	Protein Names
atrial natriuretic peptide receptor 1	ANP-A

Related Diseases

Diseases	Alias
Hypertensive Heart Disease
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Malt Worker'S Lung	Alveolitis Due To Aspergillus Clavatus Malt Worker Lung Malt Workers' Lung Malt-Workers' Lung Malt Fever Malt House Workers' Cough Malt-Workers' Alveolitis Malt-Workers' Lung Disease Alveolitis Due To Aspergillus Fumigatus Extrinsic Allergic Alveolitis Due To Aspergillus Spp
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Acromesomelic Dysplasia	Acromesomelic Dwarfism Dysplasia, Acromesomelic Acromesomelic Dysplasia Hunter-Thompson Type
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P990921	Imelciment		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P1419	AP 811	Antagonist	99.64%	Unkown
HY-153650	JS11	Inhibitor	99.22%	Unkown
HY-177062	NPRA agonist-11	Agonist	/	Unkown
HY-P1419A	AP 811 acetate	Antagonist	/	Unkown
HY-RS09497	NPR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18627	Npr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25113	Npr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P990951	Vixticibart	Agonist	97.83%	Unkown
HY-P991121	Baloncibart	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NPR1	VGNC	VGNC:75388
Canis familiaris	NPR1	VGNC	VGNC:43928
Bos taurus	NPR1	VGNC	VGNC:32213
Rattus norvegicus	NPR1	RGD	RGD:3195
Felis catus	NPR1	VGNC	VGNC:107906
Mus musculus	NPR1	MGD	MGI:97371
Others	NPR1	NCBI