PLD2 - phospholipase D2 Gene

Also Known as PLD1C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5338

About PLD2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,807,152-4,823,430 (from NCBI)

This gene has 15 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 17.0), skin (RPKM 14.6) and 23 other tissues.

Summary

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PLD2 Products (2)

mRNA Protein Name
NM_001243108.2 NP_001230037.1 phospholipase D2 isoform PLD2B
NM_002663.5 NP_002654.3 phospholipase D2 isoform PLD2A
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16407827 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLD2 Protein Structure

PX

PX: PX domain (65 - 192)

PLDc

PLDc: Phospholipase D Active site motif (437 - 464)

PLDc_2

PLDc_2: PLD-like domain (628 - 795)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 933 a.a.
Protein Preferred Names Protein Names

phospholipase D2

  • choline phosphatase 2

PLD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PLD2 O14939 CFL1 Homo sapiens P23528 17853892
Intra
PLD2 O14939 CFL1 Homo sapiens P23528 17853892
Intra
PLD2 O14939 GRB2 Homo sapiens P62993 16407827
Intra
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
Intra
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
Intra
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
Intra
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
Intra
PLD2 O14939 APP Homo sapiens P05067 32814053
Intra
PLD2 O14939 APP Homo sapiens P05067 32814053
Intra
PLD2 O14939 APP Homo sapiens P05067 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

PLD2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83818 PLD2 Antibody (YA3515) IHC-P, ICC/IF, FC, ELISA Human
HY-P83818A PLD2 Antibody (YA3515)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Parkinson Disease 6, Autosomal Recessive Early-Onset
  • Autosomal Recessive Early-Onset Parkinson Disease 6

  • Parkinson Disease 6

  • PARK6

  • Parkinson Disease 6, Early Onset

  • Parkinson'S Disease 6

  • Parkinson Disease 6, Early-Onset

  • Autosomal Recessive Early-Onset Parkinson'S Disease 6

  • Early-Onset Parkinson Disease 6

  • Autosomal Recessive Early-Onset Parkinson Disease Type 6

  • Parkinson Disease 6 Early-Onset

  • Parkinson Disease 6 Late-Onset Susceptibility To

  • Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

  • Parkinsonism Young Adult Onset

  • Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

  • Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Ewing Sarcoma
  • Neuroepithelioma

  • Ewing'S Tumor

  • Primitive Neuroectodermal Tumor

  • Ewings Sarcoma

  • Ewing'S Sarcoma

  • Peripheral Neuroepithelioma

  • ES

  • Ewings Sarcoma-Primitive Neuroectodermal Tumor

  • Localized Peripheral Primitive Neuroectodermal Tumor

  • Peripheral Primitive Neuroectodermal Tumor

  • Ewing Tumor

  • Sarcoma, Ewing'S

  • Ewing Family Of Tumors

  • Extraosseous Ewing Tumor

  • Askin Tumor

  • Ewing'S Family Localized Tumor

  • Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing Sarcoma

  • Localized Ewing'S Sarcoma

  • Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

  • Localized Ewing'S Tumor

  • Pnet Of Thoracopulmonary Region

  • Tumor Of The Ewing Family

  • Skeletal Ewing Sarcoma

  • Osseous Ewing Sarcoma

  • Ppnet

  • Peripheral Pnet

  • Extraskeletal Ewing Sarcoma

  • Eoe

  • Extraosseous Ewing Sarcoma

  • Extraskeletal Ewing Tumor

  • Esft

  • Ewing Sarcoma Family Of Tumors

  • Pne

  • Pnet

  • Pnet Of The Chest Wall

  • Sarcoma, Ewing

  • Neuroectodermal Tumors, Primitive, Peripheral

  • Neuroectodermal Tumor, Primitive

  • Disorder Of Eye

  • Askin'S Tumor

  • Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

  • Neuroepithelioma, Peripheral

Pheochromocytoma
  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant

Hermansky-Pudlak Syndrome 1
  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • HPS1

  • Delta Storage Pool Disease

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Hermansky-Pudlak Syndrome, Type 1

  • Platelet Storage Pool Deficiency

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLD2 RGD RGD:3350
Bos taurus PLD2 VGNC VGNC:32996
Mus musculus PLD2 MGD MGI:892877
Felis catus PLD2 VGNC VGNC:68902
Canis familiaris PLD2 VGNC VGNC:44661
Macaca mulatta PLD2 VGNC VGNC:76172
Others PLD2 NCBI