Pmaip1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

Also Known as Noxa

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58801

Summary

Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and negative regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and response to X-ray. Located in mitochondrion. Is expressed in several structures, including brain; immune system; limb; liver; and reproductive system. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pmaip1 Products (1)

mRNA Protein Name
NM_021451.2 NP_067426.1 phorbol-12-myristate-13-acetate-induced protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
15694340 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
12952892 MGI
involved in T cell homeostasis IMP
IMP: Inferred from mutant phenotype
18411339 MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
14699081 MGI
acts upstream of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
14500851 MGI
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
14500851 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: Inferred from direct assay
10807576 MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
16407291 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
12952892 MGI
involved in negative regulation of mitochondrial membrane potential IDA
IDA: Inferred from direct assay
14699081 MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
14500851 MGI
acts upstream of or within positive regulation of establishment of protein localization to mitochondrion IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
14500851 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15703398 MGI
involved in release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
14699081 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
12952892 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
12952892 MGI
Cellular Component GO Annotation Evidence Références Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10807576 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phorbol-12-myristate-13-acetate-induced protein 1

  • protein Noxa

Pmaip1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Pmaip1 Q9JM54 MCL1 Homo sapiens Q07820
FPS
16697956
Intra
Pmaip1 Q9JM54 Mcl1 Mus musculus P97287
ITC
17389404
Intra
Pmaip1 Q9JM54 Mcl1 Mus musculus P97287
Anti Bait CoIP
20627101
Intra
Pmaip1 Q9JM54 Mcl1 Mus musculus P97287
Anti Tag CoIP
20627101
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10758 PMAIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20580 Pmaip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27088 Pmaip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pmaip1 NCBI NCBI:5366