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SLC15A2 - solute carrier family 15 member 2 Gene

Also Known as PEPT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6565

About SLC15A2

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,894,401-121,944,188 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and 4 paralogues. Biased expression in prostate (RPKM 19.8), brain (RPKM 10.1) and 13 other tissues.

Summary

The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as Beta-lactam Antibiotics and Other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

SLC15A2 Products (2)

mRNA	Protein	Name
NM_001145998.2	NP_001139470.1	solute carrier family 15 member 2 isoform b
NM_021082.4	NP_066568.3	solute carrier family 15 member 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables dipeptide transmembrane transporter activity	IDA IDA: Inferred from direct assay	7756356	GOA
enables peptide:proton symporter activity	IDA IDA: Inferred from direct assay	7756356	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16738539	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in antibacterial innate immune response	IDA IDA: Inferred from direct assay	20406817	GOA
involved in dipeptide import across plasma membrane	IDA IDA: Inferred from direct assay	7756356	GOA

Cellular Component GO Annotation	Evidence	Références	Source
is active in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	20406817	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC15A2 Protein Structure

PTR2

0
200
400
600
729 a.a.

Protein Preferred Names	Protein Names
solute carrier family 15 member 2	kidney H(+)/peptide cotransporter

SLC15A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SLC15A2	Q16348	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	SLC15A2	Q16348	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	SLC15A2	Q16348	KRTAP15-1	Homo sapiens	Q3LI76	Validated Y2H	32296183
Intra	SLC15A2	Q16348	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	SLC15A2	Q16348	SMARCC1	Homo sapiens	Q92922	Validated Y2H	32296183
Intra	SLC15A2	Q16348	KRTAP26-1	Homo sapiens	Q6PEX3	Validated Y2H	32296183
Intra	SLC15A2	Q16348	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	32296183
Intra	SLC15A2	Q16348	C11orf87	Homo sapiens	Q6NUJ2	Validated Y2H	32296183
Intra	SLC15A2	Q16348	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	SLC15A2	Q16348	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	SLC15A2	Q16348	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	SLC15A2	Q16348	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
Intra	SLC15A2	Q16348	CHRD	Homo sapiens	Q9H2X0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coproporphyria, Hereditary	Hereditary Coproporphyria Coproporphyria Coproporphyrinogen Oxidase Deficiency HCP Cpo Deficiency Cpox Deficiency Cpx Deficiency Hereditary Coproporphyria Porphyria Cpro Deficiency Coproporphyria Hereditary Porphyria Hepatica Ii Porphyria Hepatica Coproporphyria Porphyria, Hereditary Coproporphyria Harderoporphyria
Porphyria Cutanea Tarda	Hepatoerythropoietic Porphyria HEP Uroporphyrinogen Decarboxylase Deficiency Pct Pct, Type Ii Porphyria, Hepatocutaneous Type Urod Deficiency Porphyria, Hepatoerythropoietic Porphyria Cutanea Tarda, Susceptibility To Familial Porphyria Cutanea Tarda Porphyria Cutanea Tarda, Type Ii Pct, 'Familial' Type Porphyria, Hepatic FPCT Pct Type Ii Porphyria Cutanea Tarda Type Ii Porphyria Hepatocutaneous Type Heterozygous Uroporphyrinogen Decarboxylase Deficiency Urod - [Uroporphyrinogen Decarboxylase] Deficiency Pct - [Porphyria Cutanea Tarda]
Variegate Porphyria	Porphyria Variegata Protoporphyrinogen Oxidase Deficiency VP Ppox Deficiency Porphyria, South African Type Porphyria Variegata, Susceptibility To Protocoproporphyria Porphyria Variegate Porphyria South African Type Pv Porphyria, Variegate Vp - [Variegate Porphyria]
Porphyria, Acute Intermittent	Acute Intermittent Porphyria Porphobilinogen Deaminase Deficiency Pbgd Deficiency AIP Porphyria, Swedish Type Uroporphyrinogen Synthase Deficiency Ups Deficiency Porphyria, Acute Intermittent, Nonerythroid Variant Hydroxymethylbilane Synthase Deficiency Aip - Acute Intermittent Porphyria Porphyria Intermittent Acute Pyrroloporphyria Hmbs Deficiency Porphyria Acute Intermittent
Hypotrichosis 4	HYPT4 Marie Unna Hereditary Hypotrichosis 1 Muhh1 Hypotrichosis, Marie Unna Type, 1 Hypotrichosis Marie Unna 1 Marie Unna Hereditary Hypotrichosis Type 1 Hypotrichosis, Hereditary, Marie Unna Type, 1 Hypotrichosis, Type 4
Acute Porphyria	Porphyrias, Hepatic Hepatic Porphyria Porphyria Hepatic Acute Intermittent Porphyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS13013	SLC15A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC15A2	VGNC	VGNC:65201
Rattus norvegicus	SLC15A2	RGD	RGD:61972
Macaca mulatta	SLC15A2	VGNC	VGNC:77394
Canis familiaris	SLC15A2	VGNC	VGNC:46233
Mus musculus	SLC15A2	MGD	MGI:1890457
Others	SLC15A2	NCBI