TPH1 - tryptophan hydroxylase 1 Gene

Also Known as TPRH; TRPH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7166

About TPH1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,017,555-18,046,269 (from NCBI)

This gene has 5 transcripts (splice variants), 256 orthologues and 3 paralogues. Biased expression in stomach (RPKM 7.1), colon (RPKM 5.4) and 7 other tissues.

Summary

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and Others.[provided by RefSeq, Apr 2009]

TPH1 Products (1)

mRNA	Protein	Name
NM_004179.3	NP_004170.1	tryptophan 5-hydroxylase 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPH1 Protein Structure

ACT

Biopterin_H

0
100
200
300
400
444 a.a.

Protein Preferred Names	Protein Names
tryptophan 5-hydroxylase 1	L-tryptophan hydroxylase

TPH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TPH1	P17752	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	TPH1	P17752	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	TPH1	P17752	ZMYM6	Homo sapiens	O95789-4	Y2H Pooling	32814053
Intra	TPH1	P17752	ZMYM6	Homo sapiens	O95789-4	Validated Y2H	32814053
Intra	TPH1	P17752	ZMYM6	Homo sapiens	O95789-4	Y2H Array	32814053
Intra	TPH1	P17752	DNAJC12	Homo sapiens	Q9UKB3	Anti Tag CoIP	33961781
Intra	TPH1	P17752	DNAJC12	Homo sapiens	Q9UKB3	Anti Tag CoIP	28514442
Intra	TPH1	P17752	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	TPH1	P17752	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	TPH1	P17752	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	TPH1	P17752	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	TPH1	P17752	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	TPH1	P17752	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPH1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P73566	Tryptophan Hydroxylase 1/TPH-1 Protein, Human (His)	P17752 (I2-I444)	≥ 95%, as determined by reducing SDS-PAGE.

TPH1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P83004	Tryptophan 5 Hydroxylase 1 Antibody (YA2749)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Generalized Anxiety Disorder	Anxiety Generalized
Hyperphenylalaninemia	Hyperphenylalaninaemia
Mast Cell Neoplasm	Mastocytoma Mast Cell Proliferative Disease Mast Cell Tumor Benign Mastocytoma
Borderline Personality Disorder
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Mood Disorder	Mood Disorders Episodic Mood Disorder
Conduct Disorder
Brunner Syndrome	Monoamine Oxidase A Deficiency Antisocial Behavior BRNRS Deficiency Of Monoamine Oxidase A X-Linked Monoamine Oxidase Deficiency Susceptibility To Antisocial Behavior Antisocial Behavior, Susceptibility To Anti-Social Behavior
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia	APS1 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Apeced Pga I Hypoadrenocorticism With Hypoparathyroidism And Superficial Moniliasis Autoimmune Polyendocrinopathy Syndrome , Type I, With Or Without Reversible Metaphyseal Dysplasia Polyglandular Autoimmune Syndrome, Type 1 Autoimmune Polyglandular Syndrome Type 1 Autoimmune Polyendocrine Syndrome Type 1 Autoimmune Polyendocrinopathy Syndrome Type 1 Whitaker Syndrome Aps Type 1 Polyglandular Type I Autoimmune Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome Aps I Autoimmune Polyglandular Syndrome, Type I Polyglandular Autoimmune Syndrome, Type I Aps 1 Autoimmune Polyglandular Syndrome Type I Pga 1 Pga-I Polyglandular Autoimmune Syndrome Type 1 Type I Polyglandular Autoimmune Syndrome Aire Deficiency Autoimmune Polyendocrinopathy With Candidiasis And Ectodermal Dystrophy Autoimmune Polyglandular Syndrome, Type 1 Autoimmune Polyendocrinopathy Type 1 Apeced Syndrome Autoimmune Hypoparathyroidism-Chronic Candidiasis-Addison Disease Syndrome Ham Syndrome Hypoparathyroidism-Addison Disease-Mucocutaneous Candidiasis Syndrome Medac Syndrome Multiple Endocrine Deficiency-Addison Disease-Candidiasis Syndrome Autoimmune Polyendocrine Syndrome 1, With Or Without Reversible Metaphyseal Dysplasia Aps-1 Autoimmune Polyendocrine Syndrome Type I Autoimmune Polyendocrinopathy Syndrome Type I Autosomal Dominant Autoimmune Polyendocrinopathy Syndrome Type I Polyglandular Autoimmune Syndrome Type I Polyglandular Deficiency Syndrome Persian-Jewish Type Autoimmune Polyendocrinopathy Syndrome, Type I, Autosomal Dominant Polyendocrinopathy Autoimmune, Type 1, With/Without Reversible Metaphyseal Dysplasia
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Phenylketonuria	Phenylalanine Hydroxylase Deficiency PKU Pah Deficiency Folling Disease Maternal Phenylketonuria Phenylketonurias Oligophrenia Phenylpyruvica Hyperphenylalaninemia, Non-Pku Mild Folling'S Disease Phenylalaninemia Mild Phenylketonuria Mild Pku Variant Pku Variant Phenylketonuria Mpku Deficiency Disease, Phenylalanine Hydroxylase Phenylketonuria, Maternal Phenylalanine Hydroxylase Deficiency Disease Hyperphenylalaninemic Embryopathy Maternal Pku Maternal Hyperphenylalaninemia Phenylketonuric Embryopathy Hyperphenylalaninemia HPA Non-Phenylketonuria Hyperphenylalaninemia NON-PKU HPA Phenylketonuria Maternal Classical Phenylketonuria Hyperphenylalaninaemia Pku - [Phenylketonuria]
Substance Dependence
Thyroid Dyshormonogenesis 1	TDH1 Hypothyroidism, Congenital, Due To Dyshormonogenesis, 1 Genetic Defect In Thyroid Hormonogenesis 1 Thyroid Hormonogenesis, Genetic Defect In, 1 Iodine Accumulation, Transport, Or Trapping Defect Iodide Accumulation, Transport, Or Trapping Defect Chdh1 Congenital Hypothyroidism Due To Dyshormonogenesis Type 1 Iodine Accumulation, Transport Or Trapping Defect
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Hypoadrenocorticism, Familial	Addison Disease Primary Adrenocortical Insufficiency Addison'S Disease Adrenal Gland Hypofunction Adrenal Hypoplasia Adrenal Aplasia Addison Disease, Chronic Adrenal Insufficiency Primary Hypoadrenalism Hypoadrenocorticism Familial Autoimmune Addison Disease Autoimmune Adrenalitis Classic Addison Disease Primary Addison Disease Addisons Disease Addison Disease, Susceptibility To Autoimmune Primary Adrenal Insufficiency Addison'S Disease Due To Autoimmunity
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Wissler-Fanconi Syndrome	Wissler'S Syndrome Wissler'S Subsepsis Allergica
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Hypertryptophanemia	HYPTRP Hypertryptophanemia, Familial Familial Hypertryptophanemia
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency	Sepiapterin Reductase Deficiency Spr Deficiency Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency Srd Drd Due To Srd Dopa-Responsive Hypersomnia Dyt-Spr Dyt/Park-Spr Sr-Deficient Drd Autosomal Recessive Sepiapterin Reductase-Deficient Drd Spr DRDSPRD Motor And Cognitive Disorder Due To Sepiapterin Reductase Deficiency Psychomotor Disorders
Microscopic Colitis	Colitis, Microscopic
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Lymphocytic Colitis	Colitis, Lymphocytic
Scoliosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Hyperphenylalaninemia, Bh4-Deficient, A	6-Pyruvoyl-Tetrahydropterin Synthase Deficiency Pts Deficiency HPABH4A Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To Pts Deficiency Ptsd Bh4-Deficient Hyperphenylalaninemia A Hyperphenylalaninemia Due To 6-Pyruvoyltetrahydropterin Synthase Deficiency Tetrahydobioperin-Deficient Hyperphenylalaninemia Due To Pts Deficiency Hyperphenylalanemia, Bh4-Deficient, A Hyperphenylalaninemia Due To 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency 6-Pyruvoyltetrahydropterin Synthase Deficiency Hyperphenylalaninemia Tetrahydrobiopterin-Deficient Due To Pts Deficiency Ptpsd Hyperphenylalaninemia, Bh4-Deficient, Type A
Ischemic Colitis	Colitis, Ischemic Irreversible Ischaemic Colitis
Mental Depression	Depression Depressive Disorder
Melancholia
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Aromatic L-Amino Acid Decarboxylase Deficiency	Aadc Deficiency Dopa Decarboxylase Deficiency Ddc Deficiency Aromatic Amino Acid Decarboxylase Deficiency Deficiency Of Aromatic-L-Amino-Acid Decarboxylase AADCD Aromatic-L-Amino-Acid Decarboxylase Deficiency Aromatic L-Amino-Acid Decarboxylase Deficiency
Type 1 Diabetes Mellitus 2	Diabetes Mellitus, Noninsulin-Dependent, 1 Diabetes Mellitus, Insulin-Dependent, 2 IDDM2 Insulin-Dependent Diabetes Mellitus 2 NIDDM1 Diabetes Mellitus, Noninsulin-Dependent 1 T1D2 Type 2 Diabetes Mellitus 1 T2D1 Noninsulin-Dependent Diabetes Mellitus 1 Diabetes Mellitus, Non-Insulin-Dependent, 1 Type 2 Diabetes Mellitus 1, Susceptibility To Diabetes Mellitus, Insulin-Dependent, Type 2 Diabetes Mellitus, Non-Insulin-Dependent
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Constipation
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-101124	Rodatristat ethyl	Inhibitor	99.82%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-W019599	4-Chloro-L-phenylalanine	Inhibitor	98.19%	Unkown
HY-120083	Rodatristat	Inhibitor	98.41%	Unkown
HY-157014	TPT-004	Inhibitor	99.90%	Unkown
HY-RS14932	TPH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156093	TPH1-IN-1	Inhibitor	/	Unkown
HY-RS17127	Tph1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23572	Tph1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TPH1	VGNC	VGNC:47738
Bos taurus	TPH1	VGNC	VGNC:36249
Felis catus	TPH1	VGNC	VGNC:66473
Rattus norvegicus	TPH1	RGD	RGD:3895
Mus musculus	TPH1	MGD	MGI:98796
Macaca mulatta	TPH1	VGNC	VGNC:78633
Others	TPH1	NCBI