SPAG9 - sperm associated antigen 9 Gene

Also Known as JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9043

About SPAG9

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,962,174-51,120,868 (from NCBI)

This gene has 21 transcripts (splice variants), 289 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 29.0), testis (RPKM 27.0) and 25 other tissues.

Summary

This gene encodes a member of the Cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

SPAG9 Products (4)

mRNA Protein Name
NM_001130527.3 NP_001123999.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 2
NM_001130528.3 NP_001124000.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 1
NM_001251971.2 NP_001238900.1 C-Jun-amino-terminal kinase-interacting protein 4 isoform 4
NM_003971.6 NP_003962.3 C-Jun-amino-terminal kinase-interacting protein 4 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
19644450 GOA
Biological Process GO Annotation Evidence Références Source
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
29146937 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
18826971 GOA
acts upstream of or within retrograde transport, endosome to Golgi IDA
IDA: Inferred from direct assay
19056739 GOA
Cellular Component GO Annotation Evidence Références Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
29146937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPAG9 Protein Structure

Jnk-SapK_ap_N

Jnk-SapK_ap_N: JNK_SAPK-associated protein-1 (24 - 180)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1321 a.a.
Protein Preferred Names Protein Names

C-Jun-amino-terminal kinase-interacting protein 4

  • JNK interacting protein

SPAG9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SPAG9 O60271 EXOC4 Homo sapiens Q96A65
Anti Bait CoIP
25244576
Intra
SPAG9 O60271 EXOC4 Homo sapiens Q96A65
Anti Tag CoIP
25244576
Intra
SPAG9 O60271 ARF6 Homo sapiens P62330
X-Ray Diffraction
19644450
Intra
SPAG9 O60271 ARF6 Homo sapiens P62330
Solution Sedimentation
19644450
Intra
SPAG9 O60271 ARF6 Homo sapiens P62330
SPR
19644450
Cross
SPAG9 O60271 Arf6 Mus musculus P62331
Pull Down
22522702
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Infertility
Retinitis Pigmentosa 42

  • RP42

  • Retinitis Pigmentosa-42

  • Retinitis Pigmentosa, Type 42
Subacute Leukemia
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13627 SPAG9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22820 Spag9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29335 Spag9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPAG9 VGNC VGNC:35170
Mus musculus SPAG9 MGD MGI:1918084
Felis catus SPAG9 VGNC VGNC:65599
Rattus norvegicus SPAG9 RGD RGD:1311289
Canis familiaris SPAG9 VGNC VGNC:46699
Macaca mulatta SPAG9 VGNC VGNC:77920
Others SPAG9 NCBI