GL67

GL67 lipid complexes display enlarged particle sizes and positively shifted zeta potentials as the cationic lipid-to-siRNA molar ratio rises from 1:1 to 3:1, with the 100% GL67 formulation at 3:1 generating a high positive zeta potential of 47 mV. It elevates siRNA encapsulation efficiency across all tested ratios, and complete encapsulation is attained with less GL67 at higher lipid-siRNA ratios^[1].
GL67 pentahydrochloride-based lipid complex at a 3:1 cationic lipid/siRNA molar ratio shows favorable metabolic and membrane integrity compatibility with A549 cells and boosts cellular uptake of Cy3-siRNA in A549 cells^[1].
GL67 (GL-67) mediated markedly lower gene transfection efficiency in polarized differentiated primary human and canine tracheobronchial epithelial cells cultured at the air-liquid interface, along with suppressed cell division and elevated transepithelial electrical resistance. Its transfection capacity dropped with higher cell confluence in plate-grown unpolarized human bronchial epithelial cells and declined in growth-arrested, poorly proliferative primary human bronchial epithelial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.