GYKI-47261
GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1.
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- CAS No.: 220445-20-5
- Formule: C18H15ClN4
- Masse moléculaire:322.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vivo
GYKI-47261(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57 black mice, weighing 23-30 g[1]
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Dosage:20 mg/kg
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Administration:I.p.
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Result:Reversed the MPTP-induced decrease in striatal concentrations.
Chemical Information
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CAS No. 220445-20-5
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Masse moléculaire 322.79
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Formule C18H15ClN4
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SMILES
NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Abrahám G, et al. New non competitive AMPA antagonists. Bioorg Med Chem. 2000;8(8):2127-2143. [Content Brief]
[2]. Tamási V, et al. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug Metab Dispos. 2003;31(11):1310-1314. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GYKI-47261 Related Classifications
HY-19435 Related Classifications
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