HeFi-1
HeFi-1 is a mouse anti-CD30 IgG1 monoclonal antibody. HeFi-1 recognizes the ligand-binding site on CD30. HeFi-1 can inhibit the growth of tumor cells with high expression of CD30. HeFi-1 can induce eosinophil apoptosis. HeFi-1 can be used for researches on cancer or inflammation conditions such as anaplastic large-cell lymphoma (ALCL) and asthma.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Human
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CD30 |
HeFi-1 (0.1 ng/μL, 1 h) can bind specifically to Karpas299 cells with a binding rate of over 90 %[1].
HeFi-1 (20 μg/mL, 48 h) can significantly inhibit the proliferation of Karpas299 cells and induces G1 phase blockade[1].
HeFi-1 (20 μg/mL, 12-24 h) can significantly induce apoptosis in eosinophil[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Karpas299 cells
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Concentration:20 μg/mL
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Incubation Time:48 h
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Result:Significantly inhibited cell proliferation with an inhibition rate of 40%, superior to Daclizumab (HY-108738).
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Cell Line:Karpas299 cells
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Concentration:20 μg/mL
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Incubation Time:48 h
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Result:Induced G1 phase arrest and a decrease in S phase cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1×107 Karpas299 cells injected SCID/NOD wild-type and FcRγ-/- mice[1]
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Dosage:100 μg
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Administration:Intravenous injection (i.v.), once weekly for 4 weeks
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Result:Extended the median survival time to 50.5 days in SCID/NOD wild-type mice and 42.9 days in SCID/NOD FcRγ-/- mice, significantly higher than the control group.
Significantly reduced the level of sIL-2Rα.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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ELISA, FACS, Functional assay
Chemical Information
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SMILES
N/A
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Zhang M, et al. Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors. Blood. 2006 Jul 15;108(2):705-10. [Content Brief]
[2]. Berro AI, et al. Increased expression and activation of CD30 induce apoptosis in human blood eosinophils. J Immunol. 2004 Aug 1;173(3):2174-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HeFi-1 Related Classifications
Cat. No.: HY-P991553
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