Isothiafludine
Based on 1 Customer Validation
Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.87%
- CAS No.: 960527-22-4
- Formule: C18H18FN3OS2
- Masse moléculaire:375.48
-
Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
29 μM
Compound: NZ-4; 10
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay
|
[PMID: 30594676] |
| HepG2 2.2.15 | CC50 |
50.4 μM
Compound: II-8c; NZ-4
|
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay
|
[PMID: 32712535] |
| HepG2 2.2.15 | CC50 |
51.47 μM
Compound: NZ-4
|
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay
|
[PMID: 27484509] |
| HepG2 2.2.15 | CC50 |
59.2 μM
Compound: II-8c; NZ-4
|
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay
Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay
|
[PMID: 32712535] |
| HepG2 2.2.15 | IC50 |
50.4 μM
Compound: NZ-4
|
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay
Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay
|
[PMID: 27484509] |
Isothiafludine inhibits HBV DNA replication, with an IC50 of 1.33 μM[1].
Isothiafludine (8 days) shows an IC50 (50% cytotoxicity) of 50.4 μM against HepG2.2.15 cells[1].
Isothiafludine (1.25-20 μM, 48 h) also inhibits the replication of 3TC/ETV-dual-resistant and ADV-resistant HBV mutants in virus transfected Huh7 cells[1].
Isothiafludine (10-20 μM, 8 days) decreases the levels of encapsidated HBV pgRNA in HepG2.2.15 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:DHBV-infected duck model[2]
-
Dosage:25-100 mg/kg
-
Administration:p.o., for 15 days
-
Result:Inhibited DHBV DNA in the sera on day 15.
Chemical Information
-
CAS No. 960527-22-4
-
Appearance Solid
-
Masse moléculaire 375.48
-
Formule C18H18FN3OS2
-
Color White to off-white
-
SMILES
O=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
-
Synonyms
NZ-4
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureté et documentation
-
Fiche technique (268 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isothiafludine Related Classifications
HY-111003 Related Classifications
Powered by Bioz