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Cat. No.: HY-117012

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NE58018

NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme.

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CAS No.: 105462-23-5
Formule: C₇H₁₁NO₇P₂
Masse moléculaire:283.11

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NE58018 Chemical Structure

CAS No.: 105462-23-5

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Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	8.11 μM Compound: 10	In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells) In vitro inhibitory concentration against the growth of Toxoplasma gondii in human foreskin fibroblast monolayer cells (HFF cells)	[PMID: 15857119]
RPMI-8226	EC₅₀	11 μM Compound: 2	Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTT assay	[PMID: 30016091]
RPMI-8226	EC₅₀	11 μM Compound: 2; RIS	Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation after 72 hrs by MTS assay	[PMID: 35077178]
T-cell	IC₅₀	5.6 μM Compound: 7	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL	[PMID: 14711309]
T-cell	IC₅₀	5.7 μM Compound: 7	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release	[PMID: 14711309]
Vero	IC₅₀	105 μM Compound: 9	Inhibition of Trypanosoma cruzi Amastigotes was determined in Vero cells culture and fetal calf serum Inhibition of Trypanosoma cruzi Amastigotes was determined in Vero cells culture and fetal calf serum	[PMID: 11300872]

Chemical Information

CAS No. 105462-23-5
Masse moléculaire 283.11
Formule C₇H₁₁NO₇P₂
SMILES

OC([P](O)(O)=O)([P](O)(O)=O)CC1=CC=CC=N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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NE58018

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

NE58018 Related Classifications

HY-117012 Related Classifications