NTU281
NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes.
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- CAS No.: 815619-12-6
- Formule: C25H31N2O6S+
- Masse moléculaire:487.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar Han rats [subjected to right uninephrectomy, then induced hyperglycemia by tail vein injection of streptozotocin (35 mg/kg in citrate buffer pH 4)][1]
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Dosage:2.5 μl/h of 50 mM
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Administration:Cannulated to deliver into kidneys
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Result:Reduced glomerular collagen I overexpression by ~50%; reduced the increases in glomerular Hic-5 expression; reduced diabetic nephropathy-induced α-SMA expression.
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Animal Model:Male Wistar Han rats [subjected to right uninephrectomy, then induced hyperglycemia by tail vein injection of streptozotocin (35 mg/kg in citrate buffer pH 4)][2]
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Dosage:Various concentration
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Administration:Cannulated to deliver into kidneys
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Result:Significantly reduced the increases in serum creatinine (-68%) and albuminuria (-80%) in diabetic rats during eight-month experimental period; reduced in glomerulosclerosis (-76.6%) and tubulointerstitial scarring (-68.2%) as a result of lowered accumulation of collagen I, III and IV; and reduced numbers of myofibroblasts present.
Chemical Information
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CAS No. 815619-12-6
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Masse moléculaire 487.59
-
Formule C25H31N2O6S+
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SMILES
O=C(N[C@H](C(N[C@@H](CCC(C[S+](C)C)=O)C(O)=O)=O)CC1=CC=CC=C1)OCC2=CC=CC=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Hornigold N, et al. Inhibition of collagen I accumulation reduces glomerulosclerosis by a Hic-5-dependent mechanism in experimental diabetic nephropathy. Lab Invest. 2013 May;93(5):553-65. [Content Brief]
[2]. Huang L, et al. Do changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy? Nephrol Dial Transplant. 2010 Dec;25(12):3897-910. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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