SYN1753
SYN1753 is a selective inhibitor of human neonatal Fc receptor (hFcRn) with a Kd value of 0.5 μM. SYN1753 binds to the albumin-binding site of hFcRn, inhibits the hFcRn-albumin interaction, and thereby suppresses FcRn-mediated transcytosis of human albumin. SYN1753 can be used in studies related to acetaminophen-induced liver injury.
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- Formule: C99H137N27O25S2
- Masse moléculaire:2169.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
hFcRn 0.5 μM (Kd) |
In Vitro
SYN1753 is a specific peptide inhibitor of the human FcRn-albumin interaction that binds to the albumin-specific epitope on FcRn, with a Kd of 0.5 μM at pH 6.0[1].
SYN1753 inhibits hFcRn-mediated albumin transcytosis in polarized MDCK II cells[1].
SYN1753 (1 mM; 1 h) binds to a shared site on recombinant shFcRn/β2m molecules, forming a stable complex with intramolecular disulfide bonds and putative hydrogen bonds[1].
SYN1753 inhibits the transcytosis of human albumin in both basolateral-to-apical and apical-to-basolateral directions in MDCK II cells co-expressing hFcRn and hβ2m[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 2169.44
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Formule C99H137N27O25S2
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SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H]([C@H](O)C)C(N)=O)=O)=O)=O)=O)=O)NC3=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(NCC(N[C@H]3CC7=CNC8=CC=CC=C78)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
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Sequence
Ac-Arg-Tyr-Phe-Cys-Thr-Lys-Trp-Lys-His-Gly-Trp-Cys-Glu-Glu-Val-Gly-Thr-NH2 (disulfide bridge:Cys4-Cys12)
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Sequence Shortening
Ac-RYFCTKWKHGWCEEVGT-NH2 (disulfide bridge:Cys4-Cys12)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYN1753 Related Classifications
HY-P12128 Related Classifications
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