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Tos-PEG4-t-butyl ester

(Synonyms: Tos-PEG4-Boc)
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Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM.

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  • CAS No.: 217817-01-1
  • Formule: C20H32O8S
  • Masse moléculaire:432.53
  • Stockage:
    Pure form   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Tos-PEG4-t-butyl ester Chemical Structure
    Tos-PEG4-t-butyl ester Chemical Structure
CAS No.: 217817-01-1
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  • Tos-PEG4-t-butyl ester Chemical Structure
    Tos-PEG4-t-butyl ester Chemical Structure
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  • Tos-PEG4-t-butyl ester