Cinacalcet-d4 hydrochloride
Cinacalcet-d4 (AMG-073-d4) hydrochlorideis deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
For research use only. We do not sell to patients.
- CAS No.: 2514927-75-2
- Formula: C22H19D4ClF3N
- Molecular Weight:397.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2514927-75-2
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Unlabeled CAS 364782-34-3
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Molecular Weight 397.90
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Formula C22H19D4ClF3N
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SMILES
C[C@H](C1=C2C=CC=CC2=CC=C1)NC([2H])(C([2H])(CC3=CC=CC(C(F)(F)F)=C3)[2H])[2H].Cl
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Synonyms
AMG-073-d4 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : ≥ 50 mg/mL (125.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (2.51 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76. [Content Brief]
[3]. D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5132 mL | 12.5660 mL | 25.1319 mL | 62.8299 mL |
| DMSO | 5 mM | 0.5026 mL | 2.5132 mL | 5.0264 mL | 12.5660 mL |
| 10 mM | 0.2513 mL | 1.2566 mL | 2.5132 mL | 6.2830 mL | |
| 15 mM | 0.1675 mL | 0.8377 mL | 1.6755 mL | 4.1887 mL | |
| 20 mM | 0.1257 mL | 0.6283 mL | 1.2566 mL | 3.1415 mL | |
| 25 mM | 0.1005 mL | 0.5026 mL | 1.0053 mL | 2.5132 mL | |
| 30 mM | 0.0838 mL | 0.4189 mL | 0.8377 mL | 2.0943 mL | |
| 40 mM | 0.0628 mL | 0.3141 mL | 0.6283 mL | 1.5707 mL | |
| 50 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2566 mL | |
| 60 mM | 0.0419 mL | 0.2094 mL | 0.4189 mL | 1.0472 mL | |
| 80 mM | 0.0314 mL | 0.1571 mL | 0.3141 mL | 0.7854 mL | |
| 100 mM | 0.0251 mL | 0.1257 mL | 0.2513 mL | 0.6283 mL |
Cinacalcet-d4 hydrochloride Related Classifications
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