Cinacalcet-d4 hydrochloride
Cinacalcet-d4 (AMG-073-d4) hydrochlorideis deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
For research use only. We do not sell to patients.
- CAS No.: 2514927-75-2
- Formula: C22H19D4ClF3N
- Molecular Weight:397.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2514927-75-2
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Unlabeled Cas 364782-34-3
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Molecular Weight 397.90
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Formula C22H19D4ClF3N
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SMILES
C[C@H](C1=C2C=CC=CC2=CC=C1)NC([2H])(C([2H])(CC3=CC=CC(C(F)(F)F)=C3)[2H])[2H].Cl
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Synonyms
AMG-073-d4 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : ≥ 50 mg/mL (125.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (2.51 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76. [Content Brief]
[3]. D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5132 mL | 12.5660 mL | 25.1319 mL | 62.8299 mL |
| DMSO | 5 mM | 0.5026 mL | 2.5132 mL | 5.0264 mL | 12.5660 mL |
| 10 mM | 0.2513 mL | 1.2566 mL | 2.5132 mL | 6.2830 mL | |
| 15 mM | 0.1675 mL | 0.8377 mL | 1.6755 mL | 4.1887 mL | |
| 20 mM | 0.1257 mL | 0.6283 mL | 1.2566 mL | 3.1415 mL | |
| 25 mM | 0.1005 mL | 0.5026 mL | 1.0053 mL | 2.5132 mL | |
| 30 mM | 0.0838 mL | 0.4189 mL | 0.8377 mL | 2.0943 mL | |
| 40 mM | 0.0628 mL | 0.3141 mL | 0.6283 mL | 1.5707 mL | |
| 50 mM | 0.0503 mL | 0.2513 mL | 0.5026 mL | 1.2566 mL | |
| 60 mM | 0.0419 mL | 0.2094 mL | 0.4189 mL | 1.0472 mL | |
| 80 mM | 0.0314 mL | 0.1571 mL | 0.3141 mL | 0.7854 mL | |
| 100 mM | 0.0251 mL | 0.1257 mL | 0.2513 mL | 0.6283 mL |
Cinacalcet-d4 hydrochloride Related Classifications
HY-W653978 Related Classifications
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