Cucurbit[8]uril
Based on 1 Customer Validation
Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer .
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 259886-51-6
- Formula: C48H48N32O16
- Molecular Weight:1329.10
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
![Cucurbit[8]uril Chemical Structure](https://file.medchemexpress.com/product_pic/hy-103689.gif "Click to View Cucurbit[8]uril Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Protein Heterodimerization[1]
Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2].
Cucurbit[8]uril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO-K1 cells
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Concentration:0~20 μM
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Incubation Time:48 hours
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Result:At the highest investigated concentration of 20 μM after 48 h, the relative cell viability dropped marginally to 86%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 259886-51-6
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Appearance Solid
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Molecular Weight 1329.10
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Formula C48H48N32O16
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Color White to off-white
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SMILES
O=C1N(CN(C2=O)[C@]([C@@]3([H])N2CN(C4=O)[C@]([C@@]5([H])N4CN(C6=O)[C@]([C@@]7([H])N6CN8[C@]9([H])N(C%10=O)CN%117)([H])N(C%11=O)CN%125)([H])N(C%12=O)CN3C%13=O)([H])N%13CN%14%15)[C@]%14([H])[C@]%16([H])N1CN(C%17=O)[C@@]([C@]%18([H])N%17CN(C%19=O)[C@@]([C@]%20([H])N%19CN(C%21=O)[C@@]([C@]%22([H])N%21CN%23C8=O)([H])N(C(N%22CN%10[C@]%239[H])=O)CN%24%20)([H])N(C%24=O)CN%18C%25=O)([H])N%25CN%16C%15=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Uhlenheuer DA, et al. Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins. Chem Commun (Camb). 2011;47(24):6798-6800. [Content Brief]
[2]. Uzunova VD, et al. Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem. 2010;8(9):2037-2042. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cucurbit[8]uril Related Classifications
HY-103689 Related Classifications
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